Myriad Genetics, Inc.

Molecumetics Ltd.

Patrick Douglas Boatman, Jr

Michael S Kahn

Masakatsu Eguchi

Hwa-Ok Kim

Cyprian Okwara Ogbu

There are disclosed &#x3b2;-sheet mimetics and methods relating to the same for imparting or stabilizing the &#x3b2;-sheet structure of a peptide, protein or molecule. In one aspect, &#x3b2;-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the &#x3b2;-sheet mimetic is a thrombin inhibitor.

&#x3b2;-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins

There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, &bgr;-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the &bgr;-sheet mimetic is a thrombin inhibitor.

Growing community of inventors

Issaquah, WA, United States of America

Patrick Douglas Boatman, Jr