Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Patrick Di Giorgio

Patrizio Mattei

Daniel Hunziker

Markus Rudolph

Petra Schmitz

Jerome Hert

Holger Kuehne

Jérôme Hert

Konrad H Bleicher

Theodor Stoll

Lisha Wang

Taishan Hu

Christoph Ullmer

Daniella Cheang

Justin Gomme

The present invention provides compounds of formula (I)

Peptide macrocycles against

The invention provides novel compounds having the general formula (I) wherein R, R, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.

Bicyclic compounds as ATX inhibitors

The present invention provides compounds of formula (I) 

Compounds of formula (I) wherein R, R, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.

Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors

The invention provides novel compounds having the general formula (I) wherein R, R, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.

Heterocyclic compounds useful as dual ATX/CA inhibitors

The invention provides novel compounds having the general formula (I) wherein R, Y and Rare as described herein, compositions including the compounds and methods of using the compounds.

Octahydro-cyclobuta[1,2-c;3,4-c']dipyrrol-2-yl

The invention provides novel compounds having the general formula (I) wherein R, R, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.

The invention provides novel compounds having the general formula (I) wherein R, R, R, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.

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Basel, Switzerland

Patrick Di Giorgio