Genentech, Inc.

Constellation Pharmaceuticals, Inc.

Patrick Cyr

Sarah Bronner

Fei Wang

Steven R Magnuson

F Anthony Romero

Vickie Hsiao-Wei Tsui

Kwong Wah Lai

John Wai

Kevin X Chen

Jeremy M Murray

Bing-Yan Zhu

Brian K Albrecht

Monique Bodil Van Niel

Wendy Lee

Christopher Hurley

Alexander M Taylor

James John Crawford

Richard Pastor

Andrew Peter Cridland

Benjamin Fauber

Emanuela Gancia

Stuart Ward

Terry Crawford

Alexandre Cote

Jason R Zbieg

Alexandre Côté

Olivier Rene

Alberto Gobbi

Steven Elliot Kauder

Jonathan Killen

Paul Winship

Jiangpeng Liao

Marc Adler

Jackson G Egen

The present invention relates to a compound formula (I): and to salts thereof, wherein R, RX, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Therapeutic compounds and uses thereof

The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R-Rof formula (I) and R-Rof formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Compounds of formula I: or pharmaceutical salts thereof,wherein m, n, p, q A, B, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Pyridazine derivatives as RORc modulators

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R-Rof formula (I) and R-Rof formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Growing community of inventors

South San Francisco, CA, United States of America

Patrick Cyr