Ludwig Institute for Cancer Research Limited

Patrick Chomez

Etienne De Plaen

Pierre Van Der Bruggen

Benoit Van Den Eynde

Aline Van Pel

Catia Traversari

Christophe Lurquin

Thierry Boon

Thierry R Boon-Falleur

Bernard Lethe

Charles De Smet

Jean-Pierre Szikora

The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.

Isolated tumor rejection antigen precursor proteins MAGE-2 and MAGE-3

Nucleic acid molecules encoding the MAGE-1 tumor rejection antigen precursor

Tumor rejection antigen precursors, tumor rejection antigens and uses

The invention relates to nucleic acid molecules which are useful in determining expression of the family of molecules known as the MAGE tumor rejection antigen precursors. These nucleic acid are molecules useful as diagnostic aids for determining whether or not an individual has cancer. Methods using these molecules are also described.

Isolated nucleic acid molecules useful in determining expression of a

Nucleotide sequence encoding the tumor rejection antigen precursor,

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Brussels, Belgium

Patrick Chomez