Choay, S.a.

Dropic - Societe Civile De Gestion De Droits De Propriete Industrielle

Sanofi Sa

Laboratoire C.c.d.

Prodimed

Patrick Choay

Jean-Paul Fournier

Pierre M Roger

Dominique Olliero

Claude Monneret

Alain Martin

Patrick Bouveret

Serge Weinman

An echogenic and/or radio-opaque device adapted to permit carrying out removals from the genital organs for analysis, or adapted to promote the transfer of products, particularly gametes or embryos, into the female genital organs, or again adapted to carry out tests for the introduction of catheters into the uterus and to analyze the morphology of the neck of the uterus and of the uterine cavity. The device comprises an echogenic and/or radio-opaque material permitting visualizing by medical imagery, particularly by echography or radiography, the position of the usable orifice or of the distal portion of the device.

Echogenic or radio opaque device for removal from or transfer into the genital organs

The invention relates to compositions for in vitro fertilization, or for the in vitro culture of follicles, male germinal cells or embryos, said compositions comprising at least two growth factors in association with a compound of the family of corticoids involved in energetic production in mammals. The invention also relates to the culture media obtained with these compositions, these latter being preferably in the form of a lyophilizate. The invention also has for its object processes for the in vitro fertilization and processes for maturation of follicles, of male germinal cells, or embryos using such culture media, as well as kits for the practice of these processes and comprising a lyophilizate as mentioned above and an aqueous solution, if desired commercial, containing other constituents of said culture medium.

Cellular culture medium, particularly for in vitro fertilization, or for the culture of follicles, male germ cells or embryos

The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R' can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R' represents hydrogen, and R' and R' cannot be simultaneously hydrogen atoms. These compounds present an antitumor activity.

Process for preparing nitrosourea derivatives

The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an --NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an --NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R' can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R' represents hydrogen, and R' and R' cannot be simultaneously hydrogen atoms.

Nitrosourea derivatives, process for their preparation and medicaments

The invention relates to new N-cyclic benzenesulfonamides, their process of preparation and their use as active substance of pharmaceutical compositions. The new benzenesulfonamides according to the invention correspond to the following general formula (I): ##STR1## in which: V represents, for example, hydrogen,

Cyclic benzenesulfonamides, process for their preparation and their use

The invention relates to new medicaments having lipid regulating properties nd processes for their preparation. The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the arylsulfonamide type corresponding to the formula: ##STR1## in which: Ar prepresents an aromatic ring which may if necessary be substituted;

Arylbenzenesulfonamide containing pharmaceutical compositions

Pharmaceutical compositions of N-heterocyclic benzenesulfonamides and

The invention relates to new N-substituted benzenesulfonamides, the process for their preparation and their use. The compounds according to the invention correspond to the general formula (I): ##STR1## in which: n and m have values from 0 to 4;

N-substituted 2,4-dialkoxy benzenesulfonamides and pharmaceutical

The invention relates to trisubstituted sulfohalides, the process for their preparation and their use as intermediate products for the manufacture of novel compounds. The trisubstituted sulfohalides according to the invention correspond to the following general formula (I): ##STR1## in which: X is a halogen atom, particularly bromine or preferably chlorine; R.sub.3 and R.sub.4 each represent, independently of one another, a lower alkyl radical having from 1 to 4 carbon atoms, A represents hydrogen, halogen, alkoxy radicals having from 1 to 4 carbon atoms, alkylsulfonyl groups having from 1 to 4 carbon atoms, or the group NO.sub.2, or CF.sub.3. The invention is useful in the manufacture of medicaments.

Substituted 2,4-dialkoxy benzene sulfonyl chlorides

The invention relates to new medicaments having lipid regulating properties and processes for their preparation. The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the arylsulfonamide type corresponding to the formula: ##STR1## in which: Ar represents an aromatic ring which may if necessary be substituted;

Method for treating disorders of lipid metabolism using benzene

The invention relates to new benzenesulfonyl-lactams, process for their preparation and their use as active substance in pharmaceutical compositions. Compounds according to the invention correspond to the general formula (I): ##STR1## in which: X can represent hydrogen,

Benzenesulfonyl-lactams and their use as active substances of

The invention relates to trisubstituted sulfohalides, the process for their preparation and their use as intermediate products for the manufacture of novel compounds. The trisubstituted sulfohalides according to the invention correspond to the following general formula (I): ##STR1## in which: X is a halogen atom, particularly bromine or preferably chlorine;

Substituted 2,4 dialkoxy benzene sulfonyl chlorides

Amino-4 chloro-5 methoxy-2 N-(N-ethyl methyl-2 pyrrolidino) benzenesulfonamide is a novel compound corresponding to the formula ##STR1## and is prepared by reacting sulfonyl chloride of the formula ##STR2## with the amine of the formula ##STR3## This compound and its addition salts with physiologically acceptable mineral or organic acids, is a useful medicament for the treatment of ulcerous gastro-duodenal disorders.

Growing community of inventors

Paris, France

Patrick Choay