The United States of America, as Represented by the Secretary, Department of Health and Human Services

Duke University

Patrick C Gedeon

Ira H Pastan

Darell D Bigner

John Howard Sampson

Chien-Tsun Kuan

Bryan Daehahn Choi

Bryan Choi

Mingqing Cai

Bryan D Choi

John Sampson

We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The polynucleotide is codon optimized for expression in CHO cells. The subunits of the engaging molecules are organized to achieve greater efficiency. These are therapeutic agents.

Human bispecific EGFRvIII and CD3 antibody engaging molecules

We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific. These may be used as therapeutic agents.

Human bispecific EGFRvIII antibody and CD3 engaging molecules

Growing community of inventors

Durham, NC, United States of America

Patrick C Gedeon