Warner-lambert Company

Warner Lambert LLC

Pfizer Corporation

Patrick Bernardelli

Fabrice Vergne

Pierre Ducrot

Edwige Lorthiois

Mark Ian Kemp

Henry Jacobelli

Stephen Martin Denton

Charles Andrianjara

Alexis Denis

Pierre G Ducrot

Fiona Rousseau

Febrice Vergne

Delphine Serradeil-Civit

Andrew Michael Cronin

Chrystelle Mendes

Edwige Lorth Ois

The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol and thiophenol derivatives are Hligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions. 

3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands

The invention relates to compounds of formula (I) wherein R, Rand m are as defined in the description, their use as medicament, pharmaceutical compositions containing them and a process for their preparation.

Spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III) in which X, X, X, X, X, Y, Z, A and Zare as defined in the description, methods for preparing them and their use for the treatment of disorders for which therapy by a PDE7 inhibitor is relevant.

Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors

The invention provides 1,3,4-thiadiazoles and 1,3,4-oxadiazoles having the following Formula I:in which,

Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors

The invention concerns a method for chemoselective oxidation of an organic compound comprising several potentially oxidizable groups whereof at least one is a nitrogen group. Said method is characterised in that it consists in using at least a protic solvent, which is a good donor of hydrogen bonds, enabling to limit N-oxidation.

Modifying chemoselectivity during oxidation of nitrogen compounds

A compound selected from those of formula (I):wherein:

Thiazol-2-yl-imine compounds as PDE-7 inhibitors

Oxidation of organic compounds is catalyzed by addition of a catalytic amount of a metalloporphyrin in a non-reactive aprotic solvent.

Process for catalyzing the oxidation of organic compounds

(4,2-disubstituted-thiazol-5-yl)amine compounds as PDE7 inhibitors

Method for preparing substituted &lsqb;1,4&rsqb;diazepino&lsqb;6,7,1-hi&rsqb;indol-4-ones

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Fontenay aux Roses, France

Patrick Bernardelli