Bionomics Inc.

Patrick Bazzini

Rajinder Singh

Christophe Morice

Hamish Toop

Jean-Marie Contreras

Dharam Paul

Laurent Schaeffer

Fabrice Garrido

Florence Chery

Justin Ripper

Belinda C Huff

Lorna Helen Mitchell

Erin Smith

Celine Michaut-Simon

Mathieu Michaut

The present invention relates generally to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to chemical compounds which are useful in relation to the treatment of diseases, disorders or conditions which would benefit from the modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR), such as anxiety, depression and stress related disorders.

Cyclic compounds as receptor modulating therapeutics and methods and uses thereof

Activators of Kv3.1 and/or Kv3.2 channels which are therapeutically useful in the treatment of cognitive dysfunction and the negative symptoms which are associated with central nervous system disorders such as schizophrenia, Alzheimer's disease, Tourette's syndrome, autism, dementia, epilepsy and other disorders where gamma oscillations are dysfunctional are provided. The activators include substituted N-heteroaryl compounds.

Substituted-N-heteroaryl compounds and uses thereof

The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

Substituted-pyridinyl compounds and uses thereof

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Strasbourg, France

Patrick Bazzini