University of Kansas

Patrick Andrew Ross

Mark Patrick Farrell

Jack Douglas Weiner

Suresh Eknath Kurhade

Fei Philip Gao

The present disclosure relates to compounds according to Formula I (I) or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where Ris an unsubstituted C-Calkyl; and R, R, and Rare each independently H or —C(O)—(unsubstituted C-Calkyl). Among other things, the present disclosure evidences that the significant upregulation of CD20 by the inhibition of a-mannosidase enzymes by compounds of the present technology potentiates the activity of anti-CD20 mAbs and importantly sensitize cell lines that are resistant to the action of these antibodies.

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Lawrence, KS, United States of America

Patrick Andrew Ross