Crossject

Sollac

Crossject Company

Patrick Alexandre

Bernard Brouquieres

Philippe Gautier

Denis Roller

Georges Baud

Alain Navelier

Claude Mikler

Guy Delannoy

Patrick Cognot

Joel Lafforgue

Christophe Auriel

Laurent D'Emmanuelle

Marc Piel

Christiane Reynaud

Bernard Pech

Xavière Castano

Olivier Simonin

Louis Simonet

David Desailly

Bernard Brououieres

Benoit Guichard

Jennifer Ascani

M Abdel Tazibt

Pierre Brunet

Brigitte Cagnon

An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70&#xb0; and 90&#xb0; with respect to the injection axis (B).

Injection nozzle for a needleless injection device

Needleless injection device () comprising a gas generator (), a reservoir () in the form of a glass tube () closed by an upstream stopper () and a downstream stopper () between which a liquid active principle () is accommodated, and an injection nozzle () equipped with a receptacle () and with at least one peripheral injection conduit (), said tube () having, at one of its ends, a flange () via which it is in contact with said nozzle (). The main feature of this needleless injection device () is that the tube () has a cylindrical inner channel with an upstream part () which is continued by a downstream part () of smaller diameter, said downstream part () being surrounded by said flange () and opening into the receptacle ().

Needleless injection device equipped with a protected reservoir

The present invention relates to a needleless injection device () comprising a reservoir (), obturated by an upstream stopper () and a downstream stopper () between which a liquid active principle () is accommodated, and a receptacle () comprising at least one injection conduit (), said receptacle comprising a cavity () whose height is equal to the distance traveled by the downstream stopper before each injection conduit is opened, &#x2014;the height of the cavity in millimeters being between a minimum height and a maximum height, respectively defined by the following relationships, &#x2022;minimum height=3, &#x2022;maximum height=15&#xd7;exp. (&#x2212;(V/9))+10, where V is the initial speed of ascent of the pressure profile expressed in bar per microsecond, &#x2014;the ratio between the length of each injection conduit and the height of the cavity being between 1 and 2.

Needleless injection device with double stopper with low pressure profiles

The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir () consisting of a tube () closed by an upstream plug-piston () and a downstream plug-piston () between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle () by adapting, through displacement of the downstream plug-piston () in the tube () the volume included between the two plug-pistons () to the amount of active principle () to be injected.

Needleless syringe provided with modular reservoir

A needleless injection device used for intradermal, subcutaneous and intramuscular injections is disclosed. The device includes a pyrotechnic gas generator, at least one piston, a reserve of liquid active principle and an injection nozzle. The generator includes a pyrotechnic charge composed of a central energetic material that is surrounded by a second peripheral energetic material. The entire outer surface of the central energetic material contacts the inner surface of the peripheral energetic material. The two energetic materials have different rates of combustion.

Device for needleless injection operating with two concentric energetic materials

The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container () closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore () in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore () of the receptacle.

Needleless syringe provided with a damping injector receptacle

The invention relates to an injection device which may or may not be equipped with a needle, comprising an injection nozzle and a tube which is intended to receive the active substance to be injected, whereby the tube is fixed to the nozzle using connecting means. The inventive device is characterized in that the aforementioned connecting means comprise at least three identical bosses which are solidly connected to the nozzle. Moreover, each of said bosses comprises an inclined part which terminates in a flange, said flange co-operating with a collar which is formed on the tube and acts as a backstop for the tube when the latter is connected to the nozzle.

Device for connecting an active substance container to an injection nozzle in a device used to inject said active substance

The invention concerns the field of pre-filled and disposable needleless syringes, operating with a gas generator and used for intradermal, subcutaneous and intramuscular injections of a liquid active principle for therapeutic purposes in human and veterinary medicine. Said injection device () is mainly characterized in that it has a free pressuring space () around the reservoir () of the active principle () so that the gases produced by the gas generator () instantly penetrate said pressurizing space (), compressing said reservoir () just before causing the plunger to move () to expel the liquid active principle (). During said displacement, the reservoir () is subjected to a state of equal pressure.

Needleless syringe functioning by compression of the reservoir containing the liquid active principle

The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe () comprises a cylindrical reservoir (), closed at its upstream part by a closure element () capable of being moved by driving means (), and closed at its downstream part by an injector () comprising at least an injection duct and said reservoir being secured to the body () of the syringe, said syringe is such that the diaphragm (), compatible with the active principle, isolates the latter from the injector () and said diaphragm can be passed through by the liquid () when pressurized for injection.

Needleless syringe with membrane isolating a multiple duct injector

The invention relates to a method of assembling a needleless injection device (), whereby a plurality of elements forming a circuit of elements is assembled to a body (). The aforementioned circuit comprises elements such as an initiation device, a receptacle () containing an active agent to be injected, and an active agent injection system. The inventive method is characterised in that it comprises a step in which a gas-generating cartridge (), which is adapted to the nature and/or quantity of active agent to be injected as well as to the skin penetration depth desired for same, is inserted directly into the circuit of elements, independently of said elements, from outside the body (). The invention also relates to a needleless injection device ().

Needleless injection device comprising a pyrotechnic cartridge, and method of assembling such a device

The invention relates to a needleless injection device () comprising a body () which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle () housing a liquid active agent that is to be injected, and an active agent injection system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge () which is placed in a combustion chamber (). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber ().

Needleless injection device comprising means for regulating the gas pressure level in the combustion chamber

The invention relates to the realm of needleless syringes used for injecting liquid active substances. Said syringe comprises a reservoir that is enclosed by means of displaceable plugs which trap the liquid. The reservoir is initially isolated from an injector-receptacle () which is provided with at least two peripheral injection conduits () that are arranged outside the receptacle (). Said receptacle () encompasses a pocket bore () which accommodates the plug located downstream such that the optimized inlets () of the conduits are unobstructed. The face of the receptacle (), which is located upstream, comprises a multilobed sealing joint () which is disposed parallel to and as close as possible to the edges of the bore () and the inlets (). The aim of the invention is to create an injector-receptacle () that is optimized regarding discharging and the resistance thereof to the injection pressure.

Needleless syringe comprising an optimized injector-receptacle

The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes () are mainly characterized in that they function with a pyrotechnic charge () consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (), a very high speed to the active principle (), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle () penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid ().

Needleless syringe functioning with a double-composition pyrotechnic charge

The technical field of the invention is that of needleless syringes used for intradermal, subcutaneous or intramuscular injections of active principle for therapeutic purposes. More particularly, the invention concerns a needleless syringe () comprising a propelling system, the active principle and an application guide (), mainly characterised in that the propelling system consists of an impact wave generating device () and the active principle is arranged in at least a blind cavity () of the downstream surface () of a barrier () extended by the application guide (). Thus, the active principle is expelled in the form of streamlined jets, driven at very high speed.

Needleless syringe operating with an impact wave generator through a wall

The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe () comprises a cylindrical reservoir (), closed at its upstream part by a closure element () capable of being moved by driving means (), and closed at its downstream part by an injector () comprising at least an injection duct and said reservoir being secured to the body () of the syringe, said syringe is such that the diaphragm (), compatible with the active principle, isolates the latter from the injector () and said diaphragm can be passed through by the liquid () when pressurised for injection.

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Gray, France

Patrick Alexandre