Medi-physics, Inc.

Patrick A Cella

Bastiaan Driehuys

Kenton Christopher Hasson

David L Zollinger

Daniel M Deaton

John Nouls

Brian Teixeira

Ken Bolam

Methods and devices for moisturizing hyperpolarized noble gas and associated hyperpolarized noble gas products which are formulated for inhalation or ventilation delivery include adding moisture content to (dry) hyperpolarized gas.

Methods and devices for moisturizing hyperpolarized noble gases and associated moisturized pharmaceutical grade inhalable hyperpolarized gas products

A resilient container configured to receive a quantity of hyperpolarized noble gas includes a wall with at least two layers, a first layer with a surface which minimizes spin-relaxation and a first or second layer which is substantially impermeable to oxygen. The container is especially suitable for collecting and transporting .sup.3 He. The resilient container can be configured to directly deliver the hyperpolarized noble gas to a target interface by deflating or collapsing the inflated resilient container. Related collection and transporting methods include forming the wall of the container and collecting the hyperpolarized gas in a way which minimizes its exposure to de-polarizing impurities. Also, a container includes a quantity of polarized gas and extends the T.sub.1 life by configuring the wall of the container with a controlled thickness of the surface coating and overlays the interior with an exterior which is substantially impermeable to oxygen. In addition, an O-ring and seal is configured to minimize the depolarizing effect of the collection device. Also disclosed is a method for determining the gas solubility in an unknown polymer or liquid using the measured relaxation time of a hyperpolarized gas.

Containers for hyperpolarized gases and associated methods

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Raleigh, NC, United States of America

Patrick A Cella