Beckman Coulter, Inc.

Coulter International Corp.

Patricio Vidal

Christophe P Godefroy

John Riley

Jiuliu Lu

Phaisit Chewputtanagul

Carlos Ramirez

Malek Adjouadi

Ziling Huo

Cheng Qian

Jindan Zhou

Jorge Leon

Gregory Yeager

Embodiments of the present invention encompass systems and methods for detecting the presence of a test pad on a test strip. Exemplary techniques involve receiving a test strip having at least one test pad, where individual test pads have a pad width with ink disposed on two ink zones at two opposing sides of the width of the pad, illuminating the at least one test pad with a light source, detecting reflected signals from the test pad, generating an image comprising of pixels of the two ink zones based on the reflected signals, detecting the presence of each of the ink zones by comparing the number of consecutive pixels against a predetermined threshold, and determining the presence of the test pad on the test strip if two ink zones are detected within the pad width.

Sheared pad detection systems and methods

Embodiments of the present invention encompass automated systems and methods for analyzing immature platelet parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of immature platelet conditions in the individual.

Immature platelet enumeration systems and methods

Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.

Method and apparatus for determining white blood cell counts

Methods, systems, and computer program products for the analysis of a blood sample are disclosed. One embodiment is a method of detecting and enumerating hard-to-ghost cells in a blood sample. Another embodiments is a method of analyzing reticulocytes in a blood sample. Methods of using blood count parameters are also provided.

Method and system for analyzing a blood sample

Methods, systems, and computer program products for the analysis of particle analyzer data are disclosed. One embodiment is a method of analyzing immature reticulocytes in a blood sample, including the steps of: preprocessing the blood sample; measuring the blood sample by a detection including a reticulocyte-maturity measurement and a light scatter measurement; analyzing blood cell distribution patterns to identify a set of reticulocyte events; differentiating immature reticulocytes from mature reticulocytes using the reticulocyte-maturity measurement and the light scatter measurement; and reporting immature reticulocytes. The immature reticulocyte fraction may be one aspect that is reported. Also another method is disclosed, having the steps of: measuring the blood sample by a detection comprising an axial light loss measurement; identifying a hard-to-ghost cell population based on the axial light loss measurement; filtering-out the hard-to-ghost cell population; and analyzing the event data to identify blood cell distribution patterns.

Analyzing reticulocytes

In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for displaying cellular analysis result data including accessing cellular analysis result data, accessing data of at least one template, and displaying the cellular analysis result data and the data of at least one template by overlaying the cellular analysis result data and the data of the at least one template, wherein the cellular analysis result data is displayed using different display attributes from the displayed data of the at least one template.

Displaying cellular analysis result data using a template

A signal processing operator successfully expands the dynamic range of a histogram of digital data, such as that representative of biological cell populations, including human blood cells subjected to flow cytometry processing, without introducing binning artifacts into the transformed data. The inventive data mapping scheme effectively preserves statistical probability distribution characteristics of the original data, that would otherwise be removed or lost in the course of expanding the dynamic range of a quantized histogram data set through the use of a conventional log transformation. Filtering is unnecessary, as the binning effect is countered early in the process, to preserve statistical properties of the cell populations under study.

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Miami, FL, United States of America

Patricio Vidal