Senseonics, Incorporated

Patricia Sanchez

Andrew Dehennis

Xiaoxiao Chen

Ravi Rastogi

Philip Huffstetler

Abhi Chavan

James Masciotti

Mark Mortellaro

Venkata Velvadapu

Samanwoy Ghosh-Dastidar

Methods, systems, and apparatuses for dynamic modification of calibration frequency. Dynamic modification of calibration frequency may include one or more of: receiving sensor data conveyed by an analyte sensor comprising an analyte indicator, using the sensor data to calculate one or more analyte levels, and receiving one or more reference analyte level measurements. Dynamic modification of calibration frequency may include using the sensor data, the one or more calculated analyte levels, and/or the one or more reference analyte level measurements to calculate a degradation rate of the analyte indicator of the analyte sensor. Dynamic modification of calibration frequency may include setting a dynamic calibration frequency based on the calculated degradation rate.

Dynamic modification of calibration frequency

A sensor, system, and method for detecting and correcting for an effect on an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an effect on (e.g., degradation of) the analyte indicator. The analyte sensor may also include an interferent indicator configured to exhibit a second detectable property (e.g., absorption) that varies in accordance the effect on the analyte indicator. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) an interferent measurement based on the second detectable property exhibited by the interferent indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and interferent measurements to calculate an analyte level.

Detecting and correcting for interference in an analyte monitoring system

Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM1) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RM1 and the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.

Methods and systems for weighting calibration points and updating lag parameters

Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RMand the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.

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Germantown, MD, United States of America

Patricia Sanchez