National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Georgia Research Foundation, Inc.

Patricia P Wilkins

Victor C W Tsang

Geert-Jan Boons

Conrad Padraig Quinn

Russell W Carlson

Therese Buskas

Kathy Hancock

Margreet A Wolfert

Elmar Kannenberg

Alok Mehta

Elke Saile

Ryan M Greene

Mahalakshmi Vasan

James C Allan

Biswa Choudhury

Christine Leoff

Jana Rauvolfova

The present invention presents the isolation, characterization and synthesis of oligosaccharides of. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.

Anthrax carbohydrates, synthesis and uses thereof

Compositions and methods for the detection ofand the diagnosis ofinfection are described. The nucleotide and amino acid sequences of the antigenicpolypeptides gp50, gp50and gp50are provided. The compositions contain synthetic antigenic polypeptides of larval origin prepared using the sequences described herein. Probes and primers for the detection or amplification ofnucleic acid molecules are also described. The polypeptides can be administered to a human or animal to protect againstinfection. In addition, the polypeptides are useful as research tools for studyingand as reagents in assays for the detection ofantibodies in a biological sample. The methods are sensitive and specific assays that utilize the stable recombinant or synthetic antigenic polypeptides or nucleic acid molecules encoding the larval polypeptides.

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Compositions and methods for the detection ofand the diagnosis ofinfection are described. The nucleotide and amino acid sequences of the antigenicpolypeptides gp50a, gp50b and gp50c are provided. The compositions contain synthetic antigenic polypeptides of larval origin prepared using the sequences described herein. Probes and primers for the detection or amplification ofnucleic acid molecules are also described. The polypeptides can be administered to a human or animal to protect againstinfection. In addition, the polypeptides are useful as research tools for studyingand as reagents in assays for the detection ofantibodies in a biological sample. The methods are sensitive and specific assays that utilize the stable recombinant or synthetic antigenic polypeptides or nucleic acid molecules encoding the larval polypeptides.

Compositions and methods for the detection of adult and the diagnosis and treatment of infection are described. The compositions contain one or more adult polypeptides. The polypeptides are useful as diagnostic agents for the detection of adult tapeworm infection. More preferably, the polypeptides are glycoprotein antigens referred to herein as excretory/secretory (TS/ES) polypeptides. The most preferred TS/ES polypeptide has a molecular weight of approximately 33 kDa, 38 kDa, or 42 kDa as determined by SDS-PAGE analysis.

Compositions and methods for detecting adult Taenia solium

Growing community of inventors

Gainesville, GA, United States of America

Patricia P Wilkins