Johnson and Johnson Vision Care, Inc.

Johnson Johnson Vision Care, Inc.

Transitions Optical, Inc.

Patricia Martin

Shivkumar Mahadevan

Dola Sinha

Stephen C Arnold

Leilani Keahi Sonoda

Charles W Scales

Scott L Joslin

Donnie Jerome Duis

Fang Lu

Brian Aitken

Yong Zhang

John R Buch

Dawn D Wright

Ghulam Maharvi

Jessica Cannon

Forrest R Blackburn

Donald E Riederer

Jie Xu

Joshua Hazle

Described are contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

Contact lens displaying improved vision attributes

Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices. Such devices exhibit a number of desirable properties, including favorable rates of pervaporation.

Polymerizable absorbers of UV and high energy visible light

Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.

Polymer compositions containing grafted polymeric networks and processes for their preparation and use

A method or use of a contact lens, includes applying to at least one eye of a contact lens wearer the contact lens that is a free radical reaction product of a reactive mixture that includes one or more polymerizable compounds suitable for making the contact lens; and a high energy visible (HEV) light absorbing compound; and improving, by the contact lens, at least one clinical attribute comprising overall preference of the contact lens while using computer screens and digital devices as observed by the contact lens wearer, comfort at the end of the day, CLUE Comfort score, CLUE Vision score.

Described are polymerizable high energy light absorbing compounds of formula I: Wherein Y, Pg, R, R, R, R, and Rare as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

A method of determining the transmittance of a contact lens () includes the steps of obtaining a measurement of a first intensity of electromagnetic radiation reflected by ocular surface () with an intensity measuring device (), positioning the contact lens () in direct contact with the ocular surface (), obtaining a measurement of a second intensity of electromagnetic radiation transmitted through the contact lens () that is reflected a region () of the ocular surface () that is covered by the contact lens () with the intensity measuring device (); and calculating the transmittance using the measurements of the first intensity and the second intensity.

Method and system for measuring optical characteristics of a contact lens

Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.

Ophthalmic devices derived from grafted polymeric networks and processes for their preparation and use

Provided is a contact lens system that comprises: a contact lens containing a photosensitive chromophore and a package surrounding the contact lens. The photosensitive chromophore has at least one active wavelength between 250 and 400 nanometers and at least one active wavelength between 400 and 450 nanometers. The package has a transmittance of no more than 99 percent at each active wavelength.

Contact lens containing photosensitive chromophore and package therefor

Described are polymerizable high energy light absorbing compounds of formula I: Wherein Y, Pg, R, R, R, R, R, and Rare as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Described are high energy light blocking compounds and ophthalmic devices containing the compounds. In particular, described are hydroxyphenyl naphthotriazole structures with polymerizable functionality that block high energy light and are visibly transparent. The hydroxyphenyl naphthotriazole structures can be incorporated into ophthalmic devices, such as hydrogel contact lenses, to protect eyes from high energy light radiation.

Hydroxyphenyl naphthotriazoles as polymerizable blockers of high energy light

Described are high energy light blocking compounds and ophthalmic devices containing the compounds. In particular, described are hydroxybiphenyl benzotriazole structures with polymerizable functionality that block high energy light and are visibly transparent. The hydroxybiphenyl benzotriazole structures can be incorporated into ophthalmic devices, such as hydrogel contact lenses, to protect eyes from high energy light radiation.

Polymerizable blockers of high energy light

Described are high energy light blocking compounds and ophthalmic devices containing the compounds. In particular, described are hydroxyphenyl phenanthroline structures with polymerizable functionality that block high energy light and are visibly transparent. The hydroxyphenyl phenanthroline structures can be incorporated into ophthalmic devices, such as hydrogel contact lenses, to protect eyes from high energy light radiation.

Growing community of inventors

Jacksonville, FL, United States of America

Patricia Martin