Societe Nationale Des Poudres Et Explosifs

Isochem

Patricia Hussenet

Philippe Le Goff

Gerard Sennyey

Charles-Henry Vincent

G&eacute;rard Sennyey

A process for producing N-formylleucine includes reacting leucine with formamide, precipitating the N-formylleucine, once the reaction is complete, at a temperature of approximately 0&deg; to 40&deg; C., by mixing the reaction medium with water and an acid, so that the final pH of the mixture is approximately 2 to 3, wherein the amount of water used in between approximately 1.5 and 5 parts per part by weight of starting formamide.

Process for producing N-formylleucine of high purity

The invention relates to a new process for the synthesis of a disubstituted carbodiimide, including a first stage of phosgenation of an N,N'-disubstituted urea in an organic solvent medium. After this first stage ammonia is added to the reaction mixture without preliminary isolation of any intermediate compound. The process is simple, relatively inexpensive and the yield is high. Disubstituted carbodiimides are organic synthesis intermediates used especially in pharmaceutical chemistry as coupling agents in peptide synthesis.

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Juvisy, France

Patricia Hussenet