USA As Represented by Secretary of the Navy

US Government As Represented by the Secretary of the Army

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

University of Guelph

Patricia Guerry

Mario Artur Monteiro

Yuening Jiao

Stephen Savarino

Trevor J Trust

Shahida Baqar

Frederic Poly

Brittany Michele Pequegnat

Carl Mason

Oralak Serichantalergs

Federic Poly

Lanfong H Lee

Craig Parker

Edward Burg

Frédéric Poly

The inventive subject matter relates to a construct comprising antigens derived from multiple enterobacteria includingcapsule polysaccharide polymer, enterotoxigenicrecombinant polypeptide construct and lipopolysaccharide fromspp. The subject invention also relates to a method of inducing an immune response utilizing the inventive composition.

Combined enteropathogen recombinant construct

The inventive subject matter relates to an immunogenic composition againstcomprising isolated capsule polysaccharide from selected pathogenicstrains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing an anti-immune response.

Immunogenic composition against

The invention relates to immunogenic synthetic constructs capable of inducing an immune response against() in a subject comprising one or more monosaccharides comprising one or more MeOPN moieties. Specifically, the invention relates to immunogenic synthetic constructs capable of inducing an immune response against() in a subject comprising one or more MeOPN&#x2192;6 Gal monosaccharides. The invention also relates to compositions comprising the immunogenic synthetic constructs and methods of inducing an immune response againstin a subject comprising administering the immunogenic synthetic constructs, and/or compositions comprising the immunogenic synthetic construct, to the subject.

Synthetic antigen constructs against

The invention relates to immunogenic synthetic constructs capable of inducing an immune response against() in a subject comprising one or more monosaccharides comprising one or more MeOPN moieties. Specifically, the invention relates to immunogenic synthetic constructs capable of inducing an immune response againstin a subject comprising one or more MeOPN-6-Gal monosaccharides, one or more MeOPN-4-Gal monosaccharides, and/or one or more MeOPN-2-Gal monosaccharides. The invention also relates to compositions comprising the immunogenic synthetic constructs, and methods of inducing an immune response againstin a subject comprising administering the immunogenic synthetic constructs, and/or compositions comprising the immunogenic synthetic constructs, to the subject. Methods of treating, preventing, or ameliorating abacterial infection in a subject comprising administering to the subject one or more doses of immunoglobulins directed to one or more of the MeOPN moieties are also contemplated.

Synthetic antigen constructs against campylobacter jejuni

The inventive subject matter relates to an immunogenic composition againstcomprising isolated capsule polysaccharide from selected pathogenicstrains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing and anti-immune response.

[object Object]

The inventive method and associated reagents relate to a molecular approach to determiningcapsule/Penner types. The invention also relates to a method of identifyingtypes using primers in a multiplex PCR assay.

Multiplex amplification reaction method for determination of Campylobacter jejuni Penner/capsule type

Immunogenic compositions, and method of using the compositions to elicit an immune response against. The compositions are isolated polysaccharide polymers derived fromcapsule.

An immunogenic composition, and method of using the composition, composed of a capsule polysaccharide polymer from one or more strains. The composition is either used alone or is conjugated to a carrier molecule, such as CRM. An aspect of the invention is that the immunogenic composition induces an immune response without the induction of Gulliam Barre Syndrome.

The inventive method and associated reagents relate to a molecular approach to determiningcapsule/Penner types. The invention also relates to a method of identifyingtypes using the inventive primers in a multiplex PCR assay.

An immunogenic composition, and method of using the composition to elicit an immune response to. The composition is an isolated polysaccharide polymer composed of one or more forms of disaccharide polymers.

This invention comprises a recombinant protein comprising the maltose binding protein (MBP) offused to amino acids 5&#x2013;337 of the FlaA flagellin ofVC167 which has provided evidence of immunogenicity and protective efficacy against challenge by a heterologous strain of81&#x2013;176 in mammals. The invention further comprises a recombinant DNA construct encoding the immunodominant region (region I through III) of flagellin fromspp. for use as a component of a vaccine againstdiarrhea. The invention therefore represents an effective treatment againstbut avoids inducing the autoimmune Guillain Barre Syndrome (GBS), a post-infection polyneuropathy caused bymolecular mimicry of human gangliosides which has hampered the development of vaccines heretofore.

This invention is a specific set of oligonucleotide PCR primers (pg50 and pg3) and a specific oligonucleotide probe (pBA273) for detection of PCR-amplified DNA from pathogenic strains of Campylobacter, specifically C. coli and C. jejuni, in fecal specimens.

Growing community of inventors

Silver Spring, MD, United States of America

Patricia Guerry