The Upjohn Co.

Patricia E Fast

Dale A Stringfellow

Wendell Wierenga

A method for altering the immunoregulatory system of humans and animals by administering a compound of the formula: ##STR1## wherein X.sub.3 is equal to X, X.sub.4, or X.sub.5 wherein X.sub.4 is fluoro, chloro, bromo or iodo, and X.sub.5 is mono-, di- or trihalomethyl, mono-, di or trifluoroethyl, perfluoropropyl, and wherein X is alkyl of from 1 to 3 carbon atoms, inclusive, 2-propynyl and 2-propenyl, and X.sub.1 is as defined in the specification.

Method for treating cancer with 6-aryl pyrimidine compounds

A method for treating bacterial or protozoal humans and animals by administering a 6-aryl pyrimidine compound or a salt thereof in association with a pharmaceutical carrier.

Method for treating bacterial and protozoal infections

A method for treating rejection of organ or skin grafts in humans and animals by administering 2-amino-6-aryl-5-substituted pyrimidines.

Method for treating rejection of organ or skin grafts with 6-aryl

A method for treating aplastic anemia by systemic administration of a 6-aryl pyrimidine compound or a pharmaceutically acceptable salt thereof in association with a pharmaceutical carrier to a human or animal having aplastic anemia.

6-aryl pyrimidines for treating aplastic anemia

A method for altering the immunoregulatory system of humans and animals by administering a 6 aryl pyrimidine compound or a salt thereof in association with a pharmaceutical carrier.

Method for immunoregulation with 6-aryl pyrimidine compounds

This invention relates to 6-aryl pyrimidine compounds which have now been found to be useful for treatment or prevention of arthritis.

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Kalamazoo, MI, United States of America

Patricia E Fast