University of Pennsylvania

Inovio Pharmaceuticals, Inc.

Vgx Pharmaceuticals, Inc.

Other

Advisys, Inc.

Patricia A Brown

David B Weiner

Jian Yan

Karuppiah Muthumani

Niranjan Y Sardesai

Mathura P Ramanathan

Bernadette Ferraro

Douglas R Kern

Rodney A Bowling

Ruxandra Draghia-Akli

Robert A Frosch

Alan M Lovelace

David Hood

Robert Hunt Carpenter

Amir S Khan

Joan V Danellis

Christopher E L Toote

Joan Vernikos

Clara Scott

Melissa A Pope

Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.

Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom

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Compositions and kits comprising a nucleotide sequence that encodes GHRH and a nucleotide sequence that encodes GnRH and compositions and kits comprising a GHRH protein and GnRH protein are disclosed. Use of such compositions and kits in methods of enhancing fertility in mammals comprising the step of administering said compositions to the mammal are disclosed.

Compositions comprising GHRH and GnRH and methods of using the same

One aspect of the current invention is a method of preventing and/or treating arthritis and/or preventing or treating lameness in a subject. Additionally, subject quality of life and welfare, and body condition scores are improved by utilizing methodology that administers the nucleic acid expression construct encoding a GHRH or functional biological equivalent to a subject through a parenteral route of administration. Following a single dose of nucleic acid expression vector, subjects are healthier and effects are demonstrated long term without additional administration(s) of the expression construct.

Reducing arthritis and lameness in subjects by growth hormone releasing hormone (GHRH) supplementation

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An anti-inflammatory and analgesic composition containing indomethacin and an H.sub.1 or an H.sub.2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin. Usable antagonists include pyrilamine, promethazine, metiamide and cimetidine.

Indomethacin-antihistamine combination for gastric ulceration control

An anti-inflammatory and analgesic composition containing indomethacin and an H.sub.2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin. Usable antagonists are metiamide and cimetidine.

Growing community of inventors

Magnolia, TX, United States of America

Patricia A Brown