The City University of New York

New York University

Other

Patricia A Broderick

Steven V Pacia

An electroactive photonic polymer sensing device includes an imaging component that uses photonic energy to generate a photocurrent that represents a molecular parameter, wherein the imaging component includes a photosensitive material and at least one of a laser diode and/or photodiode; and a memory component that stores a representation of the molecular parameter, wherein the memory component includes at least one of a protein, vitamin, lipid, carbon allotrope, carbon tetra fluoride. A method of sensing polymers using an electroactive photonic sensing device includes converting, using an imaging component, photonic energy into electrochemical energy to generate a photocurrent that represents a molecular parameter, wherein the imaging device includes a photosensitive material and at least one of a laser diode and/or photodiode; and storing, using a memory component, a representation of the molecular parameter, wherein the memory component includes at least one of a vitamin, lipid, carbon allotrope, carbon tetra fluoride.

Noninvasive electroactive photonic protein nanosensor with polymer photovoltaic optics for memory transduction using organic and inorganic elements as platforms

The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.

Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using electrodes with microvoltammetry

The present invention relates to devices and methods of use thereof for making semiderivative voltammetric and chronoamperometric measurements of chemicals, e.g. neurotransmitters, precursors, and metabolites, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more neurotransmitters including, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention provides methods of differentiating white matter from grey matter using microvoltammetry. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using Broderick probes. The invention further provides methods of measuring the neurotoxicity of a material by comparing Broderick probe microvoltammograms of a neural tissue in the presence and absence of the material.

Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using microelectrodes with microvoltammetry

This invention relates to a microelectrode comprising graphite, oil and, additionally, a compound selected from the group of lipids, glycolipids, lipoproteins, fatty acids, fatty acid derivatives, a water insoluble species and perfluorosulfonated compounds and salts thereof. This invention also relates to a method for using the microelectrode, a device that may be employed with the microelectrode, a method for making the microelectrode, and a method for using the device with the microelectrode.

Microelectrodes and their use in an electrochemical arrangement with

This invention relates to a microelectrode comprising graphite, oil and, additionally, a compound selected from the group of lipids, glycolipids, lipoproteins, fatty acids, fatty acid derivatives, any water insoluble species and perfluorosulfonated compounds and salts thereof. This invention also relates to a method for using the microelectrode, a device that may be employed with the microelectrode, a method for making the microelectrode, and a method for using the device with the microelectrode.

Microelectrodes and their use in a cathodic electrochemical current

This invention relates to a method for producing a cathodic, or reduction, current used in an in vivo semidifferential, semiderivative and/or semiintegral electrochemical method for achieving routine, reliable, and reproducible measurements of the dynamics of neurochemicals and neurochemical-like materials for the purpose of medical diagnosis in the body and brain of animals and in human patients. The method of this invention also permits the detection of biological markers to delineate diseased states for purposes of preventative and therapeutic medicine. Telemetric applications and automated devices for diagnostic and monitoring purposes are also described.

Growing community of inventors

Bronx, NY, United States of America

Patricia A Broderick