Bioactor Bv

Biocodex

Bioactor Bvba

Patrice D Cani

Marie-Emmanuelle Le Guern

Sam Possemiers

Tom Van De Wiele

Marc Verleye

Pieter Van Den Abbeele

Hans Van Der Saag

Audrey Martine Neyrinck

Nathalie Maria Nelly Delzenne

Amandine Everard

Peter Frank Ekhart

Lucie Geurts

Emilie Fargier

Nathalle Maria Delzenne

The present invention is directed to a particular arabinoxylan ('AX') preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium. Thus, in a further aspect the present invention provides compositions, both pharmaceutical and nutritional compositions, comprising said arabinoxylan preparations; in particular pharmaceuticals, medical foods, food supplements or food compositions, such as infant formula products, dairy products, bakery products or pastry products. The compositions optionally comprise probiotics such asor

Arabinoxylans for modulating the barrier function of the intestinal surface

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Louvain-la-Neuve, Belgium

Patrice D Cani