Commissariat a L'energie Atomique

Commissariat a L'energie Atomique Et Aux Energies Alternatives

National Institute of Health and Medical Research

Centre Hospitalier Universitaire De Grenoble

Universite Jospeh Fourier

Université Joseph Fourier

Patrice Caillat

Claude Massit

Fabien Sauter-Starace

Thierry Livache

Guy Parat

Gerard Nicolas

Pierre Puget

Charles Rosilio

Alim Louis Benabid

Patrick Pouteau

Jean-Louis Pornin

Claude Chabrol

Robert Teoule

David Henry

François Berger

Myriam-Laure Cubizolles

Pierre Blandin

Marie-Line Cosnier

Vincent Agache

Philippe Peltie

Frederic Revol-Cavalier

Alim-Louis Benabid

Anne-Gaelle Bourdat

Raymond Campagnolo

Franck Martin

Fran&ccedil;ois Marion

Stéphane Bonnet

Claude Vauchier

Magalie Faivre

Christiane Puget

Frédéric Ginot

Frédéric Revol-Cavalier

Christine Peponnet

Jean-Fr&eacute;d&eacute;ric Clerc

Virginie Brun

François Chatelain

Stephan Chabardes

Gerard Ponthenier

Nathalie Picollet-Dahan

Francois Chatelain

Fabien Sauter

Affif Zaccaria

Benoit Gilquin

Benoît Gilquin

An optically stimulating module to be integrated into a probe is implantable into a living being with a view to locally illuminating a region of said living being. The module includes a casing that is at least partially transparent, and a hermetic electronic unit placed in the casing. The hermetic electronic unit includes an internal volume housing two light sources, a control and processing unit, and a first photodetector. The module also includes a connecting device for connecting the module to a central control and power unit.

Illuminating device implantable in a living being

A device for preparing a blood sample, including a microfluidic card including: a first chamber for separating and/or extracting proteins to be analyzed that are present in the blood sample; a second chamber used for an operation involving digestion of proteins of different species that are present in the sample, to obtain a second sample containing digested peptides and nondigested proteins; and a third chamber connected to the second chamber to receive the second sample containing the digested peptides and the non-digested proteins, the third chamber being used for an operation involving purification and stabilization of the digested peptides.

Device for preparing a blood sample

A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come into contact with a different detection surface, which is arranged facing the first surface. Analytes of interest which are present in each of the drops are detected at the corresponding detection surface.

Method and microsystem for detecting analytes which are present in drops of liquid

The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells. A contacting device () according to the invention comprises: &#x2014;a sampling tip () having a contacting end intended to be introduced into a medium containing said fluid, and&#x2014;the or each capturing unit which is bound to said end and which comprises a capture substrate () defining a target capturing surface covered with at least one biocompatible and porous crosslinked polymer layer () designed to retain the or each capture substrate and only to allow biological particles including targets smaller than a limiting size to pass through, in such a way that the or each capture substrate is recoverable after said contacting by dissolution of the or each layer.

Device for transiently contacting at least one unit for capturing biological targets with a fluid containing them, method for recovering the captured targets and system for contacting and recovery

A method of counting thrombocytes contained in a sample of blood, the method having the steps: Apparatus for implementing the method.

Method and apparatus for counting thrombocytes

A device () to sample molecules of biological interest is described. The device () includes capture zones () whose developed surface area is much greater than the surface so that sampling by contact allows a sufficient quantity of molecules to be obtained to achieve reliable analysis, whilst being sized so that the device () is neither invasive nor aggressive. In particular, the device comprises tiered capture zones () located on a support () fabricated using microtechnology techniques; the capture zones () may advantageously be functionalised.

Device for contact molecular sampling

A lead for deep electrical neurostimulation comprising a rod of biocompatible material and a blade, also of biocompatible material, secured to one end of the rod and in alignment therewith. The blade presents two main faces and a plurality of electrodes disposed on at least one of the two main faces in a two-dimensional configuration. The electrodes are connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising an electrical pulse generator connected to at least one lead of the above-described type is also disclosed.

Multiple electrode lead and a system for deep electrical neurostimulation including such a lead

Probe () for deep electrical neurostimulation, and more specifically for deep brain electrostimulation, comprising:

Probe with multiple arms and system for deep electrical neurostimulation comprising such a probe

A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen. A deep electrical neurostimulation system comprising an electrical pulse generator and at least one such lead having its electrodes electrically connected to said generator.

Non-rectilinear lead and a system for deep electrical neurostimulation including such a lead

The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods. In the method of transporting an analyte present in a sample of the present invention, a solution A in which the analyte is attached to magnetic particles is prepared from the sample; the solution A is introduced into a first container connected via a bottleneck to a second container; and the analyte attached to the magnetic particles is moved, by means of a magnetic system, from the first container to the second container via the bottleneck, the second container being filled with all or part of the solution A and/or with another solution.

Methods and devices for transporting and concentrating an analyte present in a sample

A device for measuring electrical activity of biological elements, including a substrate that has lower and upper faces and at least one through opening, the opening being delimited by a set of walls. Two plates are placed on either side of the lower and upper faces of the substrate and delimit, with the set of walls, a chamber. Each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening in the substrate. Each of the plates further has at least one channel that starts inside the chamber and connects the chamber to the outside of the device, and the chamber communicates with the outside of the device only through the channels.

Device for measuring the electrical activity of biological elements and its applications

The subject of the invention is a device for chemical or biological analysis comprising a carrier () containing a plurality of analysis sites able to fix a chemical or biological reagent, in which the analysis sites are formed of microdishes () hollowed out of the carrier, the side walls and the bottom of the microdishes and the areas of the carrier surface surrounding each microdish, called microdish edges, being made in at least one hydrophilic material (), and the planar areas of the carrier arranged between the areas surrounding the microdishes being made in a hydrophobic material (). Drops () of reagent are therefore guided into the microdishes () on account of the hydrophobic areas (). It is therefore possible to increase the density of analysis sites on the carrier.

Device comprising a plurality of analysis sites on a support

Method for making a biochip and biochip

A chemical or biological analysis multi-point micro-system including a structure equipped with micro-wells, each micro-well being intended to receive a reagent coupled with a conductive polymer. Each micro-well includes a reception electrode on which the reagent is fixed by the conductive polymer with which it is coupled. Each micro-well also includes a counter-electrode arranged so as to be able to apply, in a volume of the micro-well, an electric field between its counter-electrode and its reception electrode. The structure further enables the simultaneous connection of all the reception electrodes to a first electric potential and enables the simultaneous connection of all the counter-electrodes to a second electric potential to be able to set up the electric field.

Micro-system with multiple points for chemical or biological analysis

A method and device for testing an electronic chip ( ) having on the surface a plurality of addressable electrically conductive sensitive elements ( ) in which the sensitive elements on the chip are put in contact with a conductive solution ( ), one or more sensitive elements ( ) are addressed selectively in order to apply to each sensitive element addressed an electrical test signal referred to as an input signal, and a signal, referred to as the output signal, on an electrode ( ) also in contact with the conductive solution, is measured.

Device and method for testing sensitive elements on an electronic chip

Growing community of inventors

Grenoble, France

Patrice Caillat