Merck Frosst Canada, Inc.

Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Merck Frosst Canada & Co.

Patrice C Belanger

Joshua Rokach

Yvan Guindon

Robert N Young

John W Gillard

Joseph G Atkinson

John Scheigetz

Clarence S Rooney

Haydn W Williams

David C Remy

Christiane Yoakim

Rejean Fortin

Michel L Belley

Claude Dufresne

Julian Adams

Timothy Harrison

Andrew Madin

Ian James Collins

Cheuk K Lau

Michel Therien

Martin Richard Teall

Alan John Nadin

Adrian Leonard Smith

Graeme Irvine Stevenson

Susan F Britcher

Stephen John Lewis

Timothy Jason Sparey

Joseph George Neduvelil

Mark Steven Shearman

Edward Giles McIver

Joanne Claire Hannam

John Schiegetz

Brian Fitzsimmons, Deceased

Maryann Fitzsimmons, Heir

A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.

Sulphonamido-substituted bridged bicycloalkyl derivatives

Compounds of the Formulae: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.

Leukotriene antagonists

Compounds of the formula: ##STR1## where R.sup.2 contains certain aryls or heteroaryls are effective leukotriene inhibitors.

5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis

Benzofuran derivatives, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation. The compounds are also useful as analgesics and as cytoprotective agents.

Benzofuran derivatives

4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##

4,7-benzofurandione derivatives

Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4, E.sub.4 and the slow reacting substance of anaphylaxis. As such, these compounds will be useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

Benzofuran derivatives, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation. The compounds ar also useful as analgesics and as cytoprotective agents.

Benzofuran derivatives useful as inhibitors of mammalian leukotriene

Compounds of the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic and anti-inflammatory agents.

Phenoxypropoxy halophenylacetic acids as leukotriene antagonists

4,7-benzofurandione derivatives useful as inhibitors of leukotriene

Compounds of the Formula I: ##STR1## are inhibitors of the mammalian 5-lipoxygenase enzyme system of the arachidonic acid cascade. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.

5-lipoxygenease inhibitors

Compounds of the Formula I: ##STR1## are inhibitors of the mammalian 5-lipoxygenase enzyme system of the arachidonic acid cascade. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation and are useful as cytoprotective agents.

10,11-dihydro-dibenzo-[b,f][1,4]-thiazepin derivatives

Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic and anti-inflammatory agents.

Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 E.sub.4 and the slow reacting substance of anaphylaxis. As such, these compounds will be useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

1,4-diaza-phenothiazines

Substituted phenylalkenoic acids and esters of the formula: ##STR1## having useful pharmaceutical activity are disclosed.

Growing community of inventors

Dollard des Ormeaux, Canada

Patrice C Belanger