Sanofi

Pascale Roux

Murielle Rinaldi-Carmona

Claude Vernhet

Elodie Barbagallo

Francis Barth

Serge Martinez

Laurent Hortala

Joelle Arnaud

Martine Artiaga

Carole Legeay

Joëlle Arnaud

The present invention relates to compounds corresponding to formula (I) in which: &#x2014;Rrepresents a substituted phenyl; &#x2014;Rrepresents: &#x2014;a substituted phenyl; &#x2014;a heteroaromatic group, the said group being unsubstituted or substituted one or more times; &#x2014;Rrepresents a group Alk; &#x2014;Rrepresents a hydrogen atom or a (C-C)alkyl; &#x2014;Rrepresents a hydrogen atom, a (C-C)cycloalkyl or a (C-C)alkyl-O-Alk; &#x2014;or alternatively Rand R, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; &#x2014;Rrepresents a group &#x2014;COOAlk, a group &#x2014;CONHor a group &#x2014;NHSOAlk; &#x2014;Alk represents a (C-C)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use. 

1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof

The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C-C)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; Rrepresents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; Rrepresents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from &#x2014;S-Alk, &#x2014;SO-Alk, &#x2014;SO-Alk, &#x2014;CO&#x2014;N(R)-Alk, &#x2014;N(R)SO-Alk, &#x2014;N(R)CO-Alk, &#x2014;N(R)SO&#x2014;N(Alk); Rrepresents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; Rrepresents a hydrogen atom or a (C-C)alkyl; Alk represents an unsubstituted or substituted (C-C)alkyl. Preparation process and therapeutic application. 

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The present invention is related to novel substituted 1-benzylcinnolin-4(1H)-one derivatives having affinity for cannabinoid CBreceptors, their preparation and their therapeutic application.

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Paris, France

Pascale Roux