Sanofi-aventis

Sanofi

Pascale Magat

Gihad Dargazanli

Pierre M Roger

Genevieve Estenne-Bouhtou

Benoit Marabout

Mireille Sevrin

Corinne Veronique

Florence Medaisko

Benoît Marabout

Geneviève Estenne-Bouhtou

The invention relates to use of compositions in therapeutics containing a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein.

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Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine. Moreover, the compounds of the invention may be used for treating painful muscle contracture in rheumatology and in acute spinal pathology; for treating spastic contractures of medullary or cerebral origin; for the symptomatic treatment of acute and subacute pain of light to moderate intensity; for treating intense and/or chronic pain, neurogenic pain and intractable pain; for treating Parkinson's disease and Parkinson-like symptoms of neurodegenerative origin or induced by neuroleptics; for treating partial primary and secondary generalized epilepsy of simple or complex symptomology, mixed forms and other epileptic syndromes in addition to another antiepileptic treatment, or in monotherapy, for the treatment of sleep apnea, and for neuroprotection.

Derivatives of N-phenyl (piperidine-2-yl) methyl benzamide, preparation method thereof and applications of same in therapeutics

The invention relates to compositions comprising a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

The present invention discloses and claims a compound of general formula (I) wherein A, X and Rare as described herein. Also disclosed and claimed is application of this compound in a variety of therapeutic applications.

N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy

The invention relates to a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

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Chilly Mazarin, France

Pascale Magat