Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Universitë De Bordeaux

Université D'angers

Centre Hospitalier Universitaire De Bordeaux

Centre Hospitalier Universitaire D'angers

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Pascale Jeannin

Alberto Mantovani

Glaucia Paranhos-Baccala

Thierry Delair

Yasemin Ataman-Onal

Bernard Verrier

Genevieve Inchauspe

Geneviève Inchauspe

Patrick Blanco

Jean-francois Augusto

Cecile Contin-bordes

Yahsou Delmas

Yves Delneste

Celine Beauvillain

Cécile Contin-bordes

Jean-François Augusto

Céline Beauvillain

The present invention concerns clusterin for use in the treatment of thrombotic microangiopathies, and a pharmaceutical composition comprising clusterin for use in the treatment of thrombotic microangiopathies, said composition not comprising von Willebrand factor protease. The present invention also concerns an ex vivo method for stratifying a patient suffering, or likely to be suffering, from TMA, comprising the following steps: 1) measuring, in a biological sample from said patient, the amount Lof clusterin, and 2) comparing the amount Lmeasured in step 1) with an amount Lof clusterin by calculating the score S1=L/L, in which: •If S1≤1, the patient is considered to be likely to benefit from a treatment of the TMA with clusterin, •If S1>1, the patient is not considered to be likely to benefit from treatment of TMA with clusterin.

Clusterin for use in the treatment of thrombotic microangiopathies

Nonlamellar bioresorbable microparticles to which protein substances are bonded, and a method for preparing the microparticles, comprising: (i) preparing the microparticles from at least one bioresorbable polymer without stabilizer and without surfactant; and (ii) bonding the protein substances to the microparticles obtained in step (i) without surfactant.

Bioresorbable nonlamellar microparticles and uses thereof

The present invention relates to a method for preparing nonlamellar bioresorbable microparticles to which protein substances are bonded, characterized in that it comprises the steps of: It further relates to the bioresorbable microparticles thus obtained and use thereof in diagnosis and therapy.

Method for production of bioresorbable microparticles, microparticles thus obtained and use thereof

Growing community of inventors

Bouchemaine, France

Pascale Jeannin