Commissariat a L'energie Atomique Et Aux Energies Alternatives

Commissariat a L'energie Atomique

Université Joseph Fourier

Université Grenoble Alpes

Pascale Delangle

Anaïs Pujol

Pascal Dumy

Nicolas Bremond

Sandrine Sauge-Merle

Maria-Rosa Beccia

Philippe Guilbaud

Romain Pardoux

Olivier Renaudet

Christelle Gateau

David Lemaire

Michel Ferrand

Catherine Berthomieu

Anais Pujol

The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention and/or treatment of neurodegenerative diseases, such as Wilson's disease and Alzheimer's disease, and for use in the diagnosis, prevention and/or treatment of poisoning with metal ions, such as copper and mercury ions. The invention also relates to pharmaceutical compositions comprising at least one compound having formula (I) as an active principle. 

Cyclodecapeptide compounds for use as drugs

Uranium-chelating polypeptides comprising at least one helix-loop-helix calcium-binding (EF-hand) motif which comprises a deletion of at least two amino acid in the 12-amino-acid calcium-binding loop sequence, and their use for uranium biodetection and biodecontamination.

Uranium-chelating peptides derived from EF-hand calcium-binding motif useful for uranium biodetection and biodecontamination

The present invention relates to compounds that can be used as metal-ion-chelating agents or as depolluting agents, corresponding to general formula (I) below: and also to precursor compounds of formula (II) and labelled compounds of formula (III) deriving from the compounds of formula (I). The present invention also relates to the use of the compounds (I), (II) or (III) as a medicament, and also the use thereof for the diagnosis, prevention and treatment of neurodegenerative diseases such as Wilson's disease and Alzheimer's disease.

Chelating agents of metal ions, their methods of preparation and their applications

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Voiron, France

Pascale Delangle