Commissariat a L'energie Atomique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Pascal Wodling

Nicolas Ugolin

Sylvie Chevillard

Jean-Philippe Deslys

Pierre-Yves Thro

Philippe Cormont

François Champonnois

Denis Menut

Julien Le Meur

Christian Lascoutouna

Marie Geleoc

Christophe Hubert

The present invention relates in particular to a method for the quantitative measurement of biomolecular targets that have been deposited on a biochip () of the type with a matrix of probes hybridized by the targets, the matrix comprising a multitude of measurement points () each comprising a plurality of probes, characterized in that it comprises the following steps: a) at least one laser beam () is focused onto each measurement point, in order to extract therefrom a hot confined plasma comprising a chemical element to be quantified that is present in the targets and optionally in the probes; b) the light emission lines from the plasma are detected and analysed for each measurement point, by measuring the respective intensities of these lines; and then c) the concentration in each measurement point of the element or of a group incorporating it within the targets is determined via a prior calibration of the lines establishing a correlation between the intensities of the lines specific to the element to be quantified and given concentrations of this element.

Method for the quantitative measurement of biomolecular targets deposited on a biochip, and device for implementing it

The invention concerns a method for laser ablation of a surface coating from a wall, such as a painted wall finish, for example in a nuclear plant to be decontaminated, and a device for implementing said method. The inventive ablation method includes sweeping shots on the coating of at least one pulsed laser beam with a laser beam quality factor Mless than 20, and characterized in that it comprises a direct control of said shots by optical deflection, such that the impact zones (I, I, I,) of said shots on said coating are disjointed or substantially adjacent with minimized overlapping.

Method and device for laser ablation of a surface coating from a wall, such as a coat of paint in a nuclear plant

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Orsay, France

Pascal Wodling