Trophos

Pascal Villa

Michel Delaage

Toni Williamson

Christopher Henderson

The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate () comprising an objective () for observing a stage () for positioning the plate () adapted to ensure a relative displacement between the plate () and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means () for illuminating the sample and means () for acquiring an image at the objective () output. It comprises a spacer () fixed relative to the objective () and having a support surface () on the support (), said support surface being located proximate to the observation axis, so that said spacer () is adapted to maintain, on the observation axis, a constant distance between the objective () and the observation surface (), during a relative displacement between the support () and the observation axis. The invention is useful for rapid analysis of cell samples.

Device for sequential observation of samples and methods using same

The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.

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Cassis, France

Pascal Villa