Universitè De Montpellier

Centre National De La Recherche Scientifique

Institut Europeen De Biologie Cellulaire

Université De Montpellier I

Université Montpellier II

Pascal Verdie

Jean Martinez

Anne-Marie Pinel

Gilles Subra

Pascaline Dubs

The invention relates to a dipeptide conjugate having general formula I, AA2-AA1-NH, wherein A represent the radical corresponding to a monocarboxylic acid with general formula II, HOOC&#x2014;R, in which: R represents a linear or branched aliphatic radical at C-C, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, and/or which can comprise a phenyl group or lipoic acid or the reduced form thereof, dihydrolipoic acid or N-lipoyllysine; and AA1 and AA2 represent identical or different amino acids which are selected from the group containing Ala, Asn, Cys, Gln, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Asp, Glu, Arg, His, Lys, Orn, Dap, Dab, the corresponding homo-amino acids and the corresponding beta-amino acids in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.

&#x3b1;-MSH-antagonist dipeptide conjugates

The invention relates to a tripeptide conjugate having general formula I, A-AA1-AA2-AA3-NH, wherein A represents the radical corresponding to a monocarboxylic acid with general formula II, HOOC&#x2014;R, in which: R represents a linear or branched aliphatic radical at C-C, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, lipoic acid or the reduced form thereof, dihydrolipoic acid, N-lipoyllysine, or phenylbutyric acid; and AA1, AA2 and AA3, which may be identical or different, represent independently of each other an amino acid selected from His, Phe, Ala, Arg, Lys, Orn, Trp, Nap, Tpi and Tic, on the condition that at least one of AA1, AA2 or AA3 represent Phe, preferably Dphe in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.

MSH-agonist tripeptide conjugates

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Saint Mathieu de Treviers, France

Pascal Verdie