Centre National De La Recherche Scientifique

Universitaetsklinikum Hamburg-Eppendorf

Schafer-N

Universite De La Mediterranee Aix-Marseilles 2

Universite De La Mediterranee Aix-Marseille

Pascal Torregrossa

Melitta Schachner

Claus Schafer Nielsen

Genevieve Rougon

Geneviève Rougon

A peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, comprising a B epitope of a poly-&#x3b1;2,8 sialic acid attached to NCAM which is recognized by an anti-poly-&#x3b1;2,8 sialic acid (PSA) antibody, the use thereof and the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer is disclosed.

Use of poly-&#x3b1;2,8-sialic acid mimetic peptides to modulate NCAM functions

The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-&#x3b1;2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-&#x3b1;2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.

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Marseilles, France

Pascal Torregrossa