Universite Claude Bernard – Lyon1

Institut National Des Sciences Appliquees De Lyon

Nanoh

Centre National De La Recherche Scientifique

Total Sa

Université Claude Bernard Lyon I

Hospices Civils De Lyon

European Synchrotron Radiation Facility

Oberthur Cash Protection

Université Lyon 1 Claude Bernard

Nano-h S.a.s.

Pascal Perriat

Olivier Tillement

Stéphane Roux

François Lux

Maxime Saint Jean

Pierre Mowat

Anna Mignot

Cédric Louis

Stephane Roux

Cedric Louis

Annie Commarieu

Matteo Martini

Claire Billotey

Fabrice Aubertin

Christophe Marquette

Rana Bazzi

Gilles Ledoux

Nicolas Crowther

Marc Janier

Géraldine Leduc

Brice Mutelet

Céline Mandon

Christophe Alric

Celine Mandon

Geraldine Leduc

Luc Brient

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, with diameter dbetween 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft CDTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an &#x2014;Si&#x2014;C&#x2014; covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an &#x2014;Si&#x2014;C&#x2014; covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein). The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

Ultrafine nanoparticles comprising a functionalized polyorganosiloxane matrix and including metal complexes; method for obtaining same and uses thereof in medical imaging and/or therapy

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well. The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs. This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.

Use of nanoparticles for labelling oil field injection waters

The invention concerns hybrid nanoparticles containing:

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Lyons, France

Pascal Perriat