Sanofi

Other

Societe Anonyme Sanofi

Pascal Leplatois

Richard Legoux

Pascual Ferrara

Gerard Loison

Daniel Caput

Mourad Kaghad

Jean-Claude Guillemot

Marc Louis Salome

Patrick Laurent

Evelyne Joseph-Liauzun

Johannes Lupker

Elisabeth Larbre

Adrian Minty

Brigitte Niaudet

G Erard Loison

Marilyn Magazin

David Shire

Christine Labit-Le Bouteiller

Bernard Pessegue

Evelyne L Joseph

Willem Roskam

The subject of the present invention is a protein having cytokine type activity, or a precursor of this protein, which comprises the following amino acid sequence (a1): ##STR1## in which Xaa represents Asp or Gly.

Protein having interleukin 13 activity, recombinant DNA coding for this

The invention concerns a new urate oxidase activity protein which has the following sequence (SEQ ID NO:1): ##STR1## optionally preceded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein as well as the genetic engineering implements to obtain it.

Urate oxidase activity protein, recombinant gene coding therefor,

The invention relates to an artificial promoter for the expression of proteins, especially urate oxidase in yeast, which comprises:

Artificial promoter for the expression of proteins in yeast

The invention relates to a signal peptide of the formula:

Signal peptide, DNA sequences coding for the latter, expression vectors

DNA sequence participating in the regulation of the expression of a DNA sequence coding for a precursor of a polypeptide. Expression vectors containing such a sequence. Process for the periplasmic production of a polypeptide in a strain of Gram-negative bacteria transformed by one of these vectors. Application to the production of human growth hormone.

DNA sequence participating in the regulation of the expression of a DNA

The invention relates to a microbiological process for the preparation of a protein by culturing a mutant bacterial strain. This process consists in using a bacterial strain carrying a mutation which limits, or even suppresses, the expression of the operons whose transcription depends on the fixation of the cAMP-CRP complex, a DNA sequence coding for a protein precursor having been introduced into the said bacterial strain.

Microbiological process for the preparation of a protein by culturing a

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Cuq Toulza, France

Pascal Leplatois