Universiteit Twente

Pascal Jonkheijm

Hermanus Bernardus Johannes Karperien

Jasper Van Weerd

João Francisco Ribeiro Pereira Simões Crispim

Daniël Bart Frederik Saris

The disclosure relates to a biopolymer that is functionalized with a peptide, preferably a growth factor-binding peptide. The disclosure further relates to a device comprising a functionalized biopolymer, to methods for treatment of a tissue pathology in a subject using a device according to the disclosure, to methods for coupling peptides to carbonyl groups of a biopolymer, and to a use of oxygen plasma for coupling a peptide to carbonyl groups of a biopolymer.

Functionalization of biopolymers with growth factor-binding peptides

A process for the preparation of an object, supporting a lipid bilayer, for use in tissue engineering including the steps of providing an object having a surface, treating the surface of the object with a plasma containing active oxygen to provide the surface of the object with reactive groups A, to provide the surface of the object with reactive groups A, covalently attaching a sterol group to the reactive groups A and contacting the object activated with sterol groups with a lipid solution to form a lipid bilayer.

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Enschede, Netherlands

Pascal Jonkheijm