Centre Regional De Lutte Contre Le Cancer-centre Francois Baclesse

Pascal Gauduchon

Laurent Poulain

Emilie Brotin

Ester Saison-Behmoaras

The invention relates to a double-stranded short interfering nucleic acid (siNA) molecule specific to the Bcl-Xtranscript, comprising a sense and an antisense region, wherein the sense region comprises the nucleotide sequence SEQ ID NO: 1 or a sequence having at least 70% identity, preferably at least 80% identity, more preferably at least 90% identity with said sequence, and the antisense region comprises a nucleotide sequence that is complementary to the sense region, and its use for treating cancer.

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Plumetot, France

Pascal Gauduchon