Université Joseph Fourier

Centre National De La Recherche Scientifique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Institut National De La Sante Et De La Recherche Medicale

Commissariat a L'energie Atomique

The Joseph Fourier University of Grenoble

Université Grenoble Alpes

Pascal Dumy

Jean-Luc Coll

Didier Boturyn

Isabelle Texier-Nogues

Françoise Vinet

Antoine Hoang

Pascale Delangle

Anaïs Pujol

Olivier Renaudet

Michel Ferrand

Marie Favrot

Eric Defrancq

Marie-Christine Favrot

Catherine Ghezzi

Daniel Fagret

Laurent Riou

The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention and/or treatment of neurodegenerative diseases, such as Wilson's disease and Alzheimer's disease, and for use in the diagnosis, prevention and/or treatment of poisoning with metal ions, such as copper and mercury ions. The invention also relates to pharmaceutical compositions comprising at least one compound having formula (I) as an active principle. 

Cyclodecapeptide compounds for use as drugs

The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.

Target vector with activable imaging function

The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to the solid supports functionalised by said compounds and to the use of same for the immobilisation of biological molecules of interest, such as nucleic acid molecules.

Coupling agents comprising a photolabile protecting group and uses thereof, such as for the functionalisation of solid supports

A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.

Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells

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Allevard, France

Pascal Dumy