Aventis Pharma S.a.

Sanofi-a Ventis Deutschland Gmbh

Sanofi

Pascal Desmazeau

Baptiste Ronan

Eric Bacque

Jean-Claude Barriere

Heinz-Werner Kleemann

Serge Mignani

Jean-Christophe Carry

Michel Tabart

Arielle Genevois-Borella

Jean Bouquerel

Yves Ribeill

Fabrice Viviani

Gilles Doerflinger

Catherine Souaille

Frank Halley

Gilles Dutruc-Rosset

Daniel Achard

Serge Grisoni

Jean-Pierre Leconte

Alain Le Brun

Gérard Puchault

Michel Evers

Bruno Filoche-Romme

Hervé Bouchard

Jean-Paul Martin

Jean-Philippe Letallec

Laurence Gauzy-Lazo

Odile Angouillant-Boniface

Pierre Yves Abecassis

Jean Bououerel

Baptisite Ronan

Pierre-Yves Abecassis

The invention relates to pyrazole derivatives of general formula (I): in which X represents chlorine or fluorine; to a process for preparing said derivatives, and to therapeutic uses of said derivatives.

Pyrazole derivatives, preparation thereof, and therapeutic use thereof

The invention relates to compounds of formula (I): wherein Ra, R1, Ar, L, A, W, Y, and Z are as defined in the disclosure; to compositions containing them; and to the preparation and use thereof, in particular as anticancer agents.

Substituted pyrrolopyridines, compositions containing them, manufacturing process therefor and use thereof

The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, pharmaceutical compositions comprising such derivatives, methods of treatment comprising administering such derivatives, and processes for their preparation.

3-guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them

The disclosure concerns substituted pyrroles of formula (I): wherein A, L, Ar, R1, R2, R5, and Ra are as defined in the disclosure, compositions containing the same, methods for making the same and uses thereof, in particular as anti-cancer agents.

Substituted pyrroles, compositions containing same, method for making same and use thereof

Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.

Substituted indazoles, compositions containing the same, and the preparation and use thereof

The present invention discloses and claims pharmaceutical compositions comprising Group A streptogramin derivatives of formula (I) and salts thereof in combination with at least one natural group B streptogramin derivative 

Streptogramin derivatives and compositions thereof

The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.

Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom

Group A streptogramin derivatives of general formula (I) in which: 

Streptogramin derivatives, their preparation and compositions containing them

The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-pyrrole derivatives of formula (I) wherein Rto Rand Ar are as defined herein, pharmaceutical compositions comprising such derivatives, methods of treatment comprising administering such derivatives, and processes for their preparation 

Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them

Group B streptogramin derivatives of general formula (I) are disclosed:wherein Ra, Rb, Rc, Rd, R, Rand Y are as defined in the description, including preparation methods and compositions containing the same. Such derivatives are particularly useful as antimicrobial agents, optionally combined with at least one group A streptogramin derivative.

Streptogramin derivatives, preparation method and compositions containing same

Group A streptogramin derivatives of formula (I) and salts thereof:and Group A streptogramin derivatives of formula (III) and salts thereof:as well as processes for preparing such streptogramins, and pharmaceutical compositions comprising such streptogramins, alone or combined with at least one group B streptogramin derivative.

Streptogramin derivatives, their preparation and compositions which contain them

Group B streptogramin derivatives of general formula (I):wherein Ra, Rb, Rc, Rd, R, Rand Y are as defined in the description, including preparation methods and compositions containing same. Such derivatives are particularly useful as antimicrobial agents, optionally combined with at least one group A streptogramin derivative.

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Tigery, France

Pascal Desmazeau