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Novo Nordisk A/s

Adir Et Compagnie

Université Libre De Bruxelles

Universitéde Liége

Novo Nordisk Ais

Maes, Paul

Pascal De Tullio

Bernard Pirotte

Pierre Lestage

Pierre Renard

Daniel-Henri Caignard

Jacques Delarge

Laurence Danober

Stéphane Boverie

Philippe Lebrun

Pierre Francotte

John Bondo Hansen

Flemming E Nielsen

Holger C Hansen

Fabian Somers

John Patrick Mogensen

Jean Lepagnol

Brigitte Evrard

Didier Cataldo

Paul Maes

Bernard Masereel

Pierre Fraikin

Isabelle Kempen

Sophie Sebille

Tina M&oslash;ller-Tagmose

Gilles Dufour

Marie-Hélène Antoine

Emmanuel Graindorge

The present invention relates to novel and useful pharmaceutical compositions formulated with a cyclodextrin compound and a budesonide derivative for the treatment and/or prevention of pulmonary inflammatory disease. The present invention also relates to a novel and useful analytical technique for the detection and the quantification of HP-&#x3b2;-CD in solution. More specifically, the present invention relates to the use of a validated 1H NMR analysis for the detection and quantification of cyclodextrins directly in pharmaceutical formulations without any extraction or separation steps for liquid formulations.

Cyclodextrin and budesonide derivative compositions and methods

Compounds of formula (I): wherein: Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.

Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compositions containing them

The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof. wherein:R, R, Rand Rare independently hydrogen, halogen, C-alkyl, C-cycloalkyl, hydroxy, C-alkoxy, C-alkoxy-C-alkyl, nitro, amino, cyano, cyanomethyl, perhalomethyl, C-monoalkyl- or dialkylamino, sulfamoyl, C-alkylthio, C-alkylsulfonyl, C-alkylsulfinyl, formyl, C-alkylcarbonylamino, Rarylthio, Rarylsulfinyl, Rarylsulfonyl, C-alkoxycarbonyl, C-alkoxycarbonyl-C-alkyl, carbamoyl, carbamoylmethyl, C-monoalkyl- or dialkylaminocarbonyl, C-monoalkyl- or dialkylaminothiocarbonyl, ureido, C-monoalkyl- or dialkylaminocarbonylamino, thioureido, C-monoalkyl- or dialkylaminothiocarbonylamino, C-monoalkyl- or dialkylaminosulfonyl, carboxy, carboxy-C-alkyl, acyl, Raryl, Raryl-C-alkyl, Raryloxy;Rand Rare each independently hydrogen, C-alkyl or, Rand Rtaken together with the carbon atom to which they are attached form a 3- to 6-membered carbocyclic ring;Ris 2-, 3- or 4-pyridyl optionally mono- or polysubstituted by R;Ris 2- or 3-thienyl optionally mono- or polysubstituted substituted by RorRis phenyl optionally mono- or polysubstituted by Rwith the exception of or Rrepresenting CH;Ris hydrogen, halogen, C-alkyl, C-cycloalkyl, hydroxy, C-alkoxy, nitro, amino, cyano, cyanomethyl, perhalomethyl;or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture or any polymorphic and tautomeric form.

Benzopyran derivatives, method of production and use thereof

Compounds of formula (I): wherein: Medicinal products containing the same, which are useful as AMPA inhibitors.

Thiadiazine derivatives and use thereof as positive AMPA receptor modulators

Compounds of formula (I): wherein: Medicinal products containing the same which are useful as AMPA modulators.

Fluorinated benzothiadiazine compounds

Compound selected from those of formula (I):wherein: Medicinal products containing the same which are useful as AMPA modulators.

Benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same

1,2,4-Benzothiadiazine derivatives represented by formula

1,2,4-benzothiadiazine derivatives, their preparation and use

Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, pulmonary system, the gastrointestinal system and the endocrinologic system.

Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, their

The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.4 are as defined in the description, and medicinal products containing the same which is useful for treating a pathology related to dysfunctioning of glutamatergic neurotransmission.

Pyridothiadiazines

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Jupille, Belgium

Pascal De Tullio