Pierre Fabre Dermo-cosmetique

Centre National De La Recherche Scientifique

Henkel Kommanditgesellschaft Auf Aktien

Université Paul Sabatier (toulouse Iii)

Universite Claude Bernard – Lyon1

Pascal Bordat

Henri Cousse

Roger Tarroux

Jean-Hilaire Saurat

Isabelle Rico-Lattes

Emile Perez

Olivier Sorg

Jean-Philippe Houlmont

Georg Knuebel

Bernhard Banowski

Marco A Ciufolini

Jean-Louis Brayer

Daniel Redoules

Wolfhard Scholz

Sylvie Daunes-Marion

Willy Picoul

Marianne Waldmann-Laue

Jean-Jacques Perie

Gürkan Kaya

Natacha Frison

Martina Kampmann

Alain Mavon

Stephanie Ortanderl

Marcus Mausberg

Marion P&ouml;ppl

Jérôme Rey

Marie Charveron

Anne Doat

Guerkan Kaya

Jerome Rey

The invention relates to a medicament comprising at least one reducing alkyl-sugar monomer having a hydroxyl function which is substituted by an alkoxy radical at C-C, said medicament being preferably intended to regulate inflammatory mechanisms. The reducing sugar is preferably selected from the group containing rhamnose, fucose and glucose. The invention also relates to a cosmetic treatment method involving the topical application of a composition comprising at least one reducing alkyl-sugar monomer having a hydroxyl function which is substituted by an alkoxy radical at C-C.

Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders

The inventive compositions for topical application are characterized in that they comprises one or several hyaluronate fragments in the form of a main principle whose molecular weight ranges from 50 000 and 750 000 Da and a retinoid if necessary.

Topical compositions associating sodium hyaluronate fragments and retinoid useful for cosmetic and medical dermatology

The invention concerns the cosmetic or dermatological use of at least one compound of formula (I), wherein: R, R, R, R, Rand G are such as defined in the description as whitening and/or depigmenting agents for the skin and/or hairs and/or the hair. The invention also concerns a cosmetic method for whitening and/or lightening the skin and/or hairs and/or the hair comprising applying a composition of the invention. 

Use of polyunsaturated compounds as whitening agents

The invention concerns novel polyunsaturated compounds of formula (I) wherein: Rrepresents a R', -A-R&#x2032;group, R&#x2032;being selected from &#x2014;COOH, &#x2014;COOR, &#x2014;CONH, &#x2014;CONHR, &#x2014;CONRR, &#x2014;CHO, &#x2014;CHOH, &#x2014;CHOR, and A represents a C-Calkylene, alkenylene or alkynylene; Rrepresents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a &#x2014;OC &#x2014;(CH)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a &#x2014;R&#x2032;&#x2014;O&#x2014;Rgroup, wherein R&#x2032;is an optionally substituted arylene group or an optionally substituted heteroarylene group, and Rrepresents a hydrogen atom, a straight or branched optionally substituted C-Calkyl, a straight or branched optionally substituted C-Calkenyl, or a straight or branched C-Calkynyl group, an optionally substituted tocopheryl radical or the like, an amino acid residue, or a sugar residue. The invention also concerns the compositions, in particular cosmetic and/or dermatological compositions containing at least one compound of formula (I) as well as their use as whitening and/or depigmenting agent, and the cosmetic method using said compositions.

Polyunsaturated compounds, method for preparing same and compositions containing the same

The invention concerns particles consisting essentially of fibers of an organogelling substance in the form of xerogel (dry gel), the fibers being essentially oriented in a common direction and randomly aligned around the longest fiber. The organogelling substance is preferably 1,3: 2,4-di-O-benzylidene-D-sorbitol. Said particles, which are in the form of spindles, have interesting optical properties; they have a total light transmittance higher than 0.80, with a diffuse transmittance higher than the specular transmittance. The invention also concerns a method for preparing said particles by solvent evaporation process, by solvent diffusion/evaporation process or by shearing process. The invention finally concerns active particles consisting of said particles whereon is immobilized a dermocosmetically active principle, a dermocosmetic composition comprising said particles or said active particles and a cosmetic treatment method which consists in applying on the skin said dermocosmetic composition.

Diffusing particles based on organogelling xerogel fibers, method for preparing same and use in cosmetic formulations

The invention relates to unsaturated fatty hydroxy acid derivatives of formula (I), wherein Ris independent from each other H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom, Ris H, F, Cl, Br or CF, R is H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom and 3=n=14. Said derivatives is suitable for producing an anti-radical, anti-inflammatory and antipruritic dermocosmetologic composition and/or for treating keratinisation and pigmentation troubles and/or for improving healing.

Unsaturated fatty hydroxy acid derivatives and the dermocosmetologic use thereof

The invention relates to the use of 5,6-diphenyl-1,2,4-triazinic compounds of general formula (I), wherein cycle penetrating bonds display an ortho, meta or para indifferent substitution position, identical or different R1 and R2 represent a hydrogen, fluoride, chloride or bromine atom, C1 to C12 linear or branched alkyl, C1 A C18 linear or branched hydroxy, alkoxy poly(ethoxy)-alkoxy with a C1 to C4 alkyl fragment and an ethoxy number ranging from 1 to 4, amino or mono or di-alkylamino with a C1 to C4 alkyl fragment group, R3 represents a chlorine atom, a hydroxy, amino, a phenyl possibly 1 to 3 times substituted by a hydroxy radical situated at least in a para or phenyl position possibly 1 to 3 times substituted in an ortho, meta or para position by a C1 to C12 alkoxy or cyano or alkymino group with a C1 to C7 alkyl fragment in the form of active sun filters or light-protective agents and to cosmetic composition containing said compounds.

Monomer 5, 6-diphenyl-1.2.4-traizinic derivatives and the use thereof

The invention relates to 5,6-diphenyl-1,2,4-triazinic compounds of general formula (I), wherein identical or different R1, R2, R3 and R4 represent a hydrogen, fluoride, chloride or bromine atom, C1 to C12 linear or branched alkyl, C1 A C18 linear or branched hydroxy, alkoxy poly(ethoxy)-alkoxy with a C1 to C4 alkyl fragment and an ethoxy number ranging from 1 to 4, amino or mono or di-alkylamino with a C1 to C4 alkyl fragment group, X is ortho-, meta- or paraphenylene, 4,4'-biphenylene, 2,4- or 2,6- or 3,4- or 3,5-pyridinylene, 2,2&#x2032;-bipyridinylene, meta- or paraphenylenediamino, ethylenediamine, 2,2&#x2032;-piperazinylene, diacyl of formula -(R4CO)2-, wherein r represents a phenyl radical, a 3 to 10 carbon, phenanthrene or anthracene atoms alkyl chain except 1,4-bis(5,6-diphenyl-1,2,4-triazin-3-yl)benzene of 2,4-bis(5,6-diphenyl-1,2,4-triazin-3-yl)pyridine and of 2,6-bis(5,6-diphenyl-1,2,4-triazin-3-yl)pyridine, to cosmetic compositions containing said compounds and to the use thereof in the form of sun filters or light-protective agents.

5,6-diphenyl-1,2,4-triazinic dimeric derivatives and the use thereof in the form of sun-protective agents

The invention concerns a bioprecursor of formula (I), wherein Aand Arepresent independently of each other a radical derived from a molecule capable of being used in dermatology or in cosmetology; X and Y represent independently of each other a hydrogen atom, a hydroxy group or a C&#x2013;Calkyl group; and n represents an integer between 0 and 10 

Bioprecursors for percutaneous application

An improved stick preparation is provided which is made up of at least two separate phases and at least one phase contains spherical polymer particles which can contain a pigment. The particles provide smoothness to the preparation and can be used to provide an interesting visual appearance to the stick.

Multiphase stick preparation

The present invention relates to a skin lightening composition comprising (a) a safe and effective amount of a compound of formula (I): wherein Z is Oxygen or Sulfur, (b) an average polarity solvent, (c) a polyhydric alcohol, (d) a solid fatty alcohol, (e) a nonionic surfactant, (f) water, and (g) lecithin wherein at least a portion of the above components (a), (b), (c), (d), (e), (f) and (g) forms a liquid crystal.

Oil-in-water emulsions for reconstituting lamellarity of the lipid structure of damaged skin

Growing community of inventors

Mervilla, France

Pascal Bordat