Alembic Limited

Parven Kumar Luthra

Pandurang Balwant Deshpande

Hitarth Harshendu Acharya

Ashok Prataprai Shanishchara

Hitesh Kantilal Patel

Pinky Parikh

Sanjiv Tomer

Piyush Rana

Bharat Becharbhai Boda

Dhiraj Mohansinh Rathod

Trushar Rajanikant Shah

Ramesh Manepalli

Dharmesh Balvantrai Mistry

Jigar Kamleshbhai Patel

Kishore Khemani

Tushar Rajnikant Shah

An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.

Process for the purification of Ropinirole hydrochloride

The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.

Process for the purification of ropinirole hydrochloride

The present invention relates to an improved process for the preparation of 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-1,2,3,4-tetrahydroquinolin-2-one (Aripiprazole) having dimer impurity less than 0.15%, particularly, the present invention relates to an improved process for the preparation of 7-(4-chlorobutoxy)-3,4-dihydrocarbostyril of formula (I) having dimer impurity less than 0.5%  

Process for the preparation of aripiprazole

The present invention relates to a process for the purification of Sucralose of formula (I) which comprises acetylation of substantially impure Sucralose to its penultimate intermediate 4,1',6&#x2032;-trichloro-4,1&#x2032;,6&#x2032;-trideoxy galactosucrose penta-acetate (TOPSA) of formula (VI) followed by purification of TOPSA and then deacetylation of purified TOPSA. 

Process for purification of sucralose

The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R=R=H or R=H and R=CHor an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).

Process for the preparation of Rivastigmine

A process for the preparation of Irbesartan of formula (I) using the steps of:  

Process for preparation of Irbesartan

The present invention provides a novel process for preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, by reacting carboxylic acid having structural formula (II) with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl, PCl, POCl, PBr, POBr, and PBrin presence of diphenyl ether.

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Vadodara, India

Parven Kumar Luthra