Amgen Inc.

Partha P Chakrabarti

Celia Dominguez

Craig E Masse

Michael G Kelly

Andrew Stewart Tasker

Joseph L Kim

Ning Chen

Brian K Albrecht

Mark Henry Norman

Jean E Bemis

Liping H Pettus

Christopher Harold Fotsch

Markian Myroslaw Stec

Elizabeth M Doherty

Jiawang Zhu

Vassil I Ognyanov

Hui-Ling Wang

Xianghong Wang

Robert Michael Rzasa

James Richard Falsey

Thomas Nixey

Qingyian Liu

Anthony B Reed

Dawei Zhang

Shimin Xu

Nuria A Tamayo

Russell Graceffa

Nianhe Han

Randall W Hungate

Erin F DiMauro

Stuart C Chaffee

Paul A Tempest

Gregory J Habgood

Christopher Hulme

Jodie Katon

Premilla Arasasingham

Yunxin Y Bo

Bradley J Herberich

Kelvin K C Sham

Holly L Deak

Guo-Qiang Cao

Hongyu Liao

Maya C Thaman

Kelvin Sham

Stephanie D Geuns-meyer

John L Buchanan

Guo-Giang Cao

Frenel F Demorin

Susan Ann Tomlinson

David C Mcgowan

LipingH Pettus

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein B, R, R, R, Rand Rare d.efined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Phthalazine compounds and methods of use

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Growing community of inventors

Simi Valley, CA, United States of America

Partha P Chakrabarti