University of Southern California

Vasgene Therapeutics, Inc

Parkash Gill

Sergey Zozulya

Francis Joseph Carr

Timothy David Jones

Valery Krasnoperov

Nathalie Kertesz

Ramachandra Reddy

Amy S Lee

Ren Liu

Simon William Keen

This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

Epitope specific antibodies that bind cell surface GRP78 and their use for cancer detection

Growing community of inventors

Agoura, CA, United States of America

Parkash Gill