University of California

Parinaz Abiri

Yu-Chong Tai

Tzung Hsiai

Rene R Sevag Packard

Yuan Luo

Jianguo Ma

The present invention provides devices for characterizing regions of tissue and methods for using the same. The devices are capable of locating, identifying, and characterizing tissue regions of interest in vivo. In one embodiment, the devices are ultrasound-guided. In one embodiment, the devices use characterize regions of tissue using electrical impedance spectroscopy (EIS) sensors. In one aspect, the devices are useful in predicting plaque rupture, such as by determining the level of oxidized low density lipoprotein (oxLDL) and macrophage/foam cells present in an atheroma. In one aspect, the devices are useful in identifying metabolically active atherosclerotic lesions that are angiographically invisible.

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Los Angeles, CA, United States of America

Parinaz Abiri