Wyeth

Paresh Thakker

Fuk-Wah Sum

Mark L Behnke

Baihua Hu

Katherine Lin Lee

Lihren Chen

John C McKew

James D Clark

Steven Y Tam

Wei Li

Steve Yikkai Tam

Kevin Pong

Suzana Marusic

Valerie Clerin

Steve Yik-Kai Tam

John Caedmon Mckew

James Donald Clark

Mark Leo Behnke

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.

Methods for the use of inhibitors of cytosolic phospholipase A2

This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Methods for treating asthmatic conditions

This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Methods for treating arthritic disorders

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.

Process for making an aldehyde

Inhibitors of cytosolic phospholipase A2

N-benzhydryl indole compounds

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Boston, MA, United States of America

Paresh Thakker