University of Toronto

Paraskevi Olympia Lagaditis

Robert Harold Morris

Alexandre Mikhailine

Friederike Freutel

Christine Sui-Seng

Jessica Sonnenberg

Weiwei Zuo

Nils Meyer

The application describes catalytic materials for hydrogenation or asymmetric hydrogenation. In particular, the application describes iron(II) complexes containing tridentate diphosphine PNP ligands useful for catalytic hydrogenation.

Iron(II) catalysts containing tridentate PNP ligands, their synthesis, and use thereof

The present invention relates to catalytic materials for hydrogenation or asymmetric hydrogenation. In particular, the invention relates to iron (II) complexes containing unsymmetrical tetradentate diphosphine (PNN'P) ligands with two different nitrogen donor groups useful for catalytic transfer hydrogenation or asymmetric transfer hydrogenation of ketones, aldehydes and imines.

Iron catalysts with unsymmetrical PNN'P ligands

New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts. 

Iron(II) catalysts containing diimino-diphosphine tetradentate ligands and their synthesis

Growing community of inventors

Richmond, CA, United States of America

Paraskevi Olympia Lagaditis