Aclaris Therapeutics, Inc.

Other

Adaris Therapeutics, Inc.

Paramita Mukherjee

David R Anderson

Eric Jon Jacobsen

James Robert Blinn

Susan Landis Hockerman

Richard Heier

Paul S Changelian

Canxin Xu

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Pyrrolopyrimidine ITK inhibitors

The present invention relates to new pyrrolopyridine compounds having the structures of Formula (I)-(IV), wherein the R groups, A, B, C, D and n are as defined in the detailed description, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Substituted pyrrolopyridines as JAK inhibitors

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Carbondale, IL, United States of America

Paramita Mukherjee