USA As Represented by Secretary of the Navy

George Mason University

Parag Chitnis

Alan L Huston

Igor L Medintz

Jeffrey R Deschamps

James B Delehanty

Kimihiro Susumu

Philip E Dawson

Michael H Stewart

Eunkeu Oh

Alexander L Efros

Siddhartha Sikdar

Okhil Nag

Lauren D Field

Paul Gammell

Nashaat Rasheed

John R Cressman

Nima Akhlaghi

Elizabeth Tarbox

Paul Otto

Methods, systems, and apparatuses are disclosed for ultrasound imaging comprising Time Delay Spectrometry. A frequency swept signal can be transmitted through a medium, such as human tissue. The signal can be a low-voltage signal (e.g., 0 volts to 5 volts peak-to-peak) transmitted for long duration (e.g., 20 milliseconds) at various frequencies. As the signal propagates through the medium it can be reflected and delayed. A delay associated with the signal the can cause a change in the associated frequencies. The signal can be filtered to retain only frequencies in an audio frequency range. The signal can be beamformed and processed to produce an image.

Method and apparatus for low-power ultraportable ultrasound imaging

A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be Cfullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.

Multifunctional nanoparticle bioconjugates for photoacoustic-based recording of cellular membrane potential

Growing community of inventors

Fairfax Station, VA, United States of America

Parag Chitnis