Amgen Inc.

Paolo Vincetti

Iain Lingard

Michela Beltrani

Teodora P Damyanova

Jennifer Rebecca Allen

Ana Elena Minatti

Matthew Paul Bourbeau

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula I. wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Methods of using heterocyclic compounds as Delta-5 Desaturase inhibitors

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ('D5D'). The compounds have a general Formula I wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use

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Verona, Italy

Paolo Vincetti