F.i.s. Fabbrica Italiana Sintetici S.p.a.

F.i.s.—fabrica Italiana Sintetici S.p.a.

Paolo Stabile

Pierluigi Padovan

Angelo Restelli

Matteo De Poli

Nicolas Tesson

Francesco Fontana

Nicola Faccin

Moreno Bertolazzi

Diego Rasia

Jordi De Mier Vinue

Ottorino De Lucchi

Andrea Castellin

Marco Galvagni

Stefano Tartaggia

Stefano Fogal

Andrea Caporale

Floriana Semeraro

Jordi De Mier Vinué

Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of Eltrombopag, passing through/using intermediate 5′-Chloro-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid alkaline metal salt of formula: wherein A is an alkaline metal.

Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof

The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R, Ris independent hydrogen, acetyl, Ris hydrogen, a C1-C4 linear or branched alkyl group and Ris hydrogen or an amine protecting group. 

Enzymatic process for the preparation of Droxidopa

Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.

Highly stable crystalline Eltrombopag monoethanolamine salt form D1

Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.

Crystalline Eltrombopag monoethanolamine salt form D

An efficient process for increasing the optical purity of the active pharmaceutical ingredient Esomeprazole, by means of a substantially quantitative and selective precipitation and removal of Omeprazole is provided.

Process for the optical purification of esomeprazole

Object of the present invention is an improved process for the preparation of Esomeprazole (S)-BINOL complex which is a key intermediate for the synthesis of Esomeprazole and salts thereof.

[object Object]

The present invention relates to an efficient process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. Water is employed as reaction medium.

Very efficient process for preparing an intermediate of etoricoxib

Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.

Methods for preparing intermediates of perampanel

A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.

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Verona, Italy

Paolo Stabile