Gambro Lundia Ab

Baxter International Inc.

Baxter Healthcare Sa

Gambro Dasco S.p.a.

Gambro Hospal (Schweiz) Ag

Gambio Lundia Ab

Gambro Hospal Ag

Paolo Rovatti

Alessandro Surace

Carlo Alberto Lodi

Jan P Sternby

Kristian Solem

Thomas Hertz

Anders Nilsson

Anders Wallenborg

Fabio Roncadi

David Stefani

Mariano Ruffo

Katty Ferrari

Tom Westberg

Matthew R Muller

Francesco Paolini

Mauro Suffritti

Luca Vinci

Alessandro Vasta

James W Kendall

Renato Pedrazzi

Paolo Pirazzoli

Marco Salsa

Carlos Corrales

Fabrizio Molducci

Bruno Genovese

Michela Carpani

Enrico Ravagli

Stefano Severi

Elena Grandi

Matteo Paltrinieri

Pier Giorgio Verdi

An apparatus for extracorporeal treatment of blood () comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit () is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. An upstream variation of the value of the characteristic (Cd) is caused in the fresh treatment liquid with respect to a prescription baseline (Cd) thereby causing a corresponding and timely delayed downstream variation of the same characteristic (Cd) in the spent liquid flowing in the spent dialysate line (). An amplitude (ΔC) and/or a duration over time (ΔT) of the upstream variation are/is computed as a function of the flow rate (Qdial) of the fresh treatment liquid in a preparation line () or of the parameter correlated to the flow rate (Qdial).

Apparatus for extracorporeal treatment of blood and method for determining a parameter indicative of the progress of an extracorporeal blood treatment

Non-invasive heartbeat sensor for determining a heart rate in a conduit of an extracorporeal blood treatment apparatus, comprising one source for directing an optical signal towards the blood flowing in the segment; one detector for receiving an optical informative signal comprising the signal emitted by said source after passing the blood, and emitting respective output signal; a controller receiving the respective output signal and retrieving a heartbeat frequency and a heart rate value, based on the output signal, wherein the informative signal is altered by flow perturbation of the blood partially generated by the flow impulses originated by the heart.

Non-invasive sensor for determining a heartbeat and/or heart rate in a segment of an extracorporeal blood circuit

A mobile dialysis therapy cart includes a top shelf; a cycler compartment positioned below the top shelf, the cycler compartment sized and shaped to house an APD cycler; a fluid bag management compartment sized and shaped to house at least two fluid bags; a drain compartment positioned below the fluid bag management compartment; and a plurality of wheels. The cart may include a heating device associated with the fluid bag management compartment and/or a sanitizing light source for sanitizing a location of a disposable set associated with the fluid bags.

Multi-functional peritoneal dialysis mobile cart

An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line at a set point based on the physician prescription; starting from the initial patient plasma conductivity, estimated at the beginning of the treatment, and based on the target plasma conductivity/sodium concentration which is equivalent to the dialysate conductivity/sodium concentration prescribed, the control unit determines the minimum constant gradient between dialysis fluid and plasma conductivity/concentration to be maintained during treatment to achieve the conductivity/concentration target in the patient plasma at the end of the session.

Apparatus for extracorporeal blood treatment

An extracorporeal blood treatment apparatus comprises: a blood treatment device () comprising a blood chamber () and a fluid chamber () separated from one another by a semipermeable membrane (); an extracorporeal blood circuit () comprising a blood withdrawal line () connected to an inlet port () of the blood chamber () and a blood return line () connected to an outlet port () of the blood chamber (); a blood pump () configured to be coupled to the blood withdrawal line (); a hydraulic circuit () connectable to the fluid chamber (), wherein the hydraulic circuit () comprises a fluid preparation device () connected to a water network () and configured to dilute concentrates in water to prepare a treatment fluid; a control unit () connected to the preparation device () and to the blood pump (). The control unit () is configured to execute the following procedure: setting the hydraulic circuit () so that the fluid preparation device () bypasses the fluid chamber (); controlling the fluid preparation device () to prepare the treatment fluid while bypassing the fluid chamber (); and simultaneously controlling the blood pump () to perform pure ultrafiltration of a patient (P) connected to the extracorporeal blood circuit ().

Extracorporeal blood treatment method

An apparatus for extracorporeal treatment of blood () comprising a treatment unit (), a blood withdrawal line (), a blood return line (), a preparation line () and a spent dialysate line (); a non-invasive blood volume sensor () for determining an additional property of blood is active on a tube segment () of the blood withdrawal line or of the blood return line; the sensor includes one source () for directing a signal towards the blood, a plurality of detectors () for receiving the signal, and a controller () receiving the output signals from the detectors () and determining a blood volume variation and a value of sodium concentration in the blood (Na) both based on the output signals. A process of determining at least one parameter and on property of blood circulating an extracorporeal blood circuit is also disclosed.

Sensor and apparatus for determining at least one parameter of blood circulating in an extracorporeal blood circuit

An extracorporeal blood treatment apparatus includes a filtration unit () connected to a blood circuit () and a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating of the dialysis fluid up to the calculating of the initial plasma conductivity performed by maintaining the dialysis fluid conductivity substantially constant.

There is provided an IV infusion set comprising a patient access configured to connect to a vascular system of a patient, a source of medical fluid, an infusion line having one first end configured to connect to the source of medical fluid and one opposite second end configured to deliver the medical fluid towards the patient access, an infusion apparatus arranged on the infusion line, a sensor configured to emit a pressure signal indicative of a pressure of a medical fluid in the infusion line, and a control unit configured to receive the pressure signal and to determine a patient signal indicative of a vital signal of the patient based on the pressure signal. The IV infusion set further comprises a compliance element configured to attenuate pressure variations of medical fluid the infusion line, and a resistance element configured to reflect pressure waves moving along the infusion line. The sensor is arranged on the infusion line at a position downstream from the resistance element with respect to a direction of fluid flow along the infusion line from the medical fluid source towards the patient access. The infusion line may include a main infusion line and/or one or more auxiliary infusion lines connected to a main infusion line.

Infusion set for measuring vital signals of a patient comprising a compliance element and a reflective element

Extracorporeal blood treatment apparatus

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid; a control unit () is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line () at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

A method of operating an extracorporeal blood treatment includes, prior to commencing an extracorporeal blood treatment, reading from a storage device () stored values of a patient-specific prescription parameter. These stored values relate to a sequence of previous extracorporeal blood treatments. In addition, the method includes processing the stored values of the parameter read from the storage device () according to a predetermined algorithm to determine a current value of the patient-specific prescription parameter. The current value is then available for the subsequent extracorporeal blood treatment.

Extracorporeal blood treatment system for individualized treatment

Extracorporeal blood treatment apparatus having dialysis fluid parameter data entry

Extracorporeal blood treatment apparatus () and methods as described herein involve control of blood line pressure utilizing a non-invasive pressure sensor ().

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Finale Emilia, Italy

Paolo Rovatti